On the origin of neurons 英文参考文献.docVIP

Meeting report On the origin of neurons Jeremy N Pulvers, Judith Schenk, Yoko Arai, Ji-Feng Fei, Kanako Saito and Wieland B Huttner Address: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse, D-01307 Dresden, Germany. Correspondence: Wieland B Huttner. Email: huttner@mpi-cbg.de Published: 31 July 2007 Genome Biology 2007, 8:311 (doi:10.1186/gb-2007-8-7-311) The electronic version of this article is the complete one and can be found online at /2007/8/7/311 ? 2007 BioMed Central Ltd the hippocampus, giving rise to neuronal progenitors that A report on the conference ‘Neurogenesis 2007’, Tokyo, Japan, 15-16 May 2007. produce neurons throughout life. Neuronal progenitors in the dorsal telencephalon of rodent embryos fall into two major classes: those that divide at the apical surface (neuroepithelial and radial glial cells, collec- tively referred to as apical progenitors) and those that divide at the basal side of the ventricular zone and in the sub- ventricular zone and serve as an intermediate progenitor in the lineage from apical progenitors to neurons (called either basal progenitors or intermediate progenitors and here referred to as basal intermediate progenitor cells). Although it has been known that basal intermediate progenitor cells exist from the very onset of neurogenesis throughout all of its stages, a question has been whether they serve as distinct progenitors for specific lineages or layers, or as a general intermediate population to boost neurogenic output for all layers. Using various markers of apical progenitors and basal intermediate progenitor cells, Robert Hevner (University of Washington, Seattle, USA) delineated a transcription factor cascade associated with neurogenesis (Pax6→ Ngn1, Ngn2→ Tbr2→ Tbr1). Hevner presented evidence establishing Tbr2 as a marker for basal intermediate progenitor cells. Using a Tbr2-GFP transgenic mouse