On the significance of Surfactant Protein-A within the human lungs 英文参考文献.docVIP

Diagnostic Pathology BioMedCentral Review Open Access On the significance of Surfactant Protein-A within the human lungs Torsten Goldmann*, Daniel K?hler, Holger Schultz, Mahdi Abdullah, Dagmar S Lang, Florian Stellmacher and Ekkehard Vollmer Address: Division for Clinical and Experimental Pathology, Research Center Borstel, Borstel, Germany Email: Torsten Goldmann* - tgoldmann@fz-borstel.de; Daniel K?hler - dkaehler@fz-borstel.de; Holger Schultz - hschultz@fz-borstel.de; Mahdi Abdullah - mabdull@fz-borstel.de; Dagmar S Lang - dlang@fz-borstel.de; Florian Stellmacher - fstellmacher@fz-borstel.de; Ekkehard Vollmer - evollmer@fz-borstel.de * Corresponding author Published: 12 March 2009 Received: 6 March 2009 Accepted: 12 March 2009 Diagnostic Pathology 2009, 4:8 doi:10.1186/1746-1596-4-8 This article is available from: /content/4/1/8 ? 2009 Goldmann et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Surfactant Protein-A (SP-A) is the most prominent among four proteins in the pulmonary surfactant-system. SP-A is expressed by alveolar epithelial cells type II as well as by a portion of non small cell lung carcinomas (NSCLC). The expression of SP-A is complexly regulated on the transcriptional and the chromosomal level. SP-A is a major player in the pulmonary cytokine-network and moreover has been described to act in the pulmonary host defense. By the use of cell culture or animal models the functional properties have been repeatedly shown in many aspects, often bearing surprising properties which strongly indicate the physiological importance of SP-A. To date SP-A is recognized as a molecule essential for pulmonary development, structure and function. An upcoming