Oral malignant melanomas and other head and neck neoplasms in Danish dogs - data from the Danish Veterinary Cancer Registry 英文参考文献.docVIP

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Oral malignant melanomas and other head and neck neoplasms in Danish dogs - data from the Danish Veterinary Cancer Registry 英文参考文献.doc

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Oral malignant melanomas and other head and neck neoplasms in Danish dogs - data from the Danish Veterinary Cancer Registry 英文参考文献

Acta Veterinaria Scandinavica BioMedCentral Research Open Access Oral malignant melanomas and other head and neck neoplasms in Danish dogs - data from the Danish Veterinary Cancer Registry Louise B Br?nden, Thomas Eriksen* and Annemarie T Kristensen Address: Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Dyrl?gevej 16, DK-1870 Frederiksberg C, Denmark Email: Louise B Br?nden - lobb@life.ku.dk; Thomas Eriksen* - ter@life.ku.dk; Annemarie T Kristensen - atk@life.ku.dk * Corresponding author Published: 18 December 2009 Received: 22 May 2009 Accepted: 18 December 2009 Acta Veterinaria Scandinavica 2009, 51:54 doi:10.1186/1751-0147-51-54 This article is available from: /content/51/1/54 ? 2009 Br?nden et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Head and neck cancers (HNC) are relatively common and often very serious diseases in both dogs and humans. Neoplasms originating in the head and neck region are a heterogeneous group. HNC often has an unfavourable prognosis and the proximity of the tissue structures renders extirpation of tumours with sufficient margins almost incompatible with preservation of functionality. In humans oral malignant melanoma (OMM) is extremely rare, but represents a particular challenge since it is highly aggressive as is the canine counterpart, which thus may be of interest as a spontaneous animal model. Methods: Canine cases entered in the Danish Veterinary Cancer Registry (DVCR) from May 15th 2005 through February 29th 2008 were included in this study. Fishers exact test was used to compare proportions of HNC in dogs and humans as well as proportions of surgically treated