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Optimizing Experimental Design for Comparing Models of Brain Function 英文参考文献.doc

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Optimizing Experimental Design for Comparing Models of Brain Function 英文参考文献

OptimizingExperimentalDesignforComparingModels ofBrainFunction JeanDaunizeau1,2*,KerstinPreuschoff2,KarlFriston1,KlaasStephan1,2 1WellcomeTrustCentreforNeuroimaging,UniversityCollegeofLondon,London,UnitedKingdom,2LaboratoryforSocialandNeuralSystemsResearch,Departmentof Economics,UniversityofZurich,Zurich,Switzerland Abstract This article presents the first attempt to formalize the optimization of experimental design with the aim of comparing modelsofbrainfunctionbasedonneuroimagingdata.WedemonstrateourapproachinthecontextofDynamicCausal Modelling(DCM),whichrelatesexperimentalmanipulationstoobservednetworkdynamics(viahiddenneuronalstates)and providesaninferenceframeworkforselectingamongcandidatemodels.Here,weshowhowtooptimizethesensitivityof modelselectionbychoosingamongexperimentaldesignsaccordingtotheirrespectivemodelselectionaccuracy.Using Bayesiandecisiontheory,we(i)derivetheLaplace-Chernoffriskformodelselection,(ii)discloseitsrelationshipwithclassical designoptimalitycriteriaand(iii)assessitssensitivitytobasicmodellingassumptions.Wethenevaluatetheapproachwhen identifyingbrainnetworksusingDCM.Monte-CarlosimulationsandempiricalanalysesoffMRIdatafromasimplebimanual motortaskinhumansservetodemonstratetherelationshipbetweennetworkidentificationandtheoptimalexperimental design. For example, we show that deciding whether there is a feedback connection requires shorter epoch durations, relativetoaskingwhetherthereisexperimentallyinducedchangeinaconnectionthatisknowntobepresent.Finally,we discusslimitationsandpotentialextensionsofthiswork. Citation: Daunizeau J, Preuschoff K, Friston K, Stephan K (2011) Optimizing Experimental Design for Comparing Models of Brain Function. PLoS Comput Biol7(11):e1002280.doi:10.1371/journal.pcbi.1002280 Editor:OlafSporns,IndianaUniversity,UnitedStatesofAmerica ReceivedJune25,2011;AcceptedOctober5,2011;PublishedNovember17,2011 Copyright: ?2011 Daunizeau et al. This isan open-access article distributed under the terms of the CreativeCommo