Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo 英文参考文献.docVIP

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Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo 英文参考文献.doc

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Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo 英文参考文献

Available online /content/12/1/R27 Research Open Access Vol 12 No 1 Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo Stephanie Nonas1, Anna A Birukova2, Panfeng Fu2, Jungjie Xing2, Santipongse Chatchavalvanich2, Valery N Bochkov3, Norbert Leitinger4, Joe GN Garcia2 and Konstantin G Birukov2 1Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA 2Department of Medicine, University of Chicago, 5801 South Ellis St, Chicago, IL 60637, USA 3Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria 4Cardiovascular Research Center, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908, USA Corresponding author: Konstantin G Birukov, kbirukov@ Received: 7 Aug 2007 Revisions requested: 13 Sep 2007 Revisions received: 3 Jan 2008 Accepted: 24 Jan 2008 Published: 24 Jan 2008 Critical Care 2008, 12:R27 (doi:10.1186/cc6805) This article is online at: /content/12/1/R27 ? 2008 Nonas et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Mechanical ventilation at high tidal volume (HTV) may cause pulmonary capillary leakage and acute lung inflammation resulting in ventilator-induced lung injury. Besides blunting the Toll-like receptor-4-induced inflammatory cascade and lung dysfunction in a model of lipopolysaccharide-induced lung injury, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3- phosphorylcholine (OxPAPC) exerts direct barrier-protective effects on pulmonary endothelial cells in vitro via activation of the small GTPases Rac and Cdc42. To test the hypothesis that OxPAPC may attenuate lung inflammation and