Poststroke Depression and Risk of Recurrent Stroke at 1 Year in a Chinese Cohort Study 英文参考文献.docVIP

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Poststroke Depression and Risk of Recurrent Stroke at 1 Year in a Chinese Cohort Study 英文参考文献.doc

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Poststroke Depression and Risk of Recurrent Stroke at 1 Year in a Chinese Cohort Study 英文参考文献

PoststrokeDepressionandRiskofRecurrentStrokeat1 YearinaChineseCohortStudy HuaiWuYuan1*,ChunXueWang1*,NingZhang1,YingBai1,YuZhiShi1,YongZhou1,YiLongWang1, TongZhang1,JuanZhou2,XinYu3,XinYuSun3,ZhaoRuiLiu3,XingQuanZhao1,YongJunWang1 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 2Department of Neurology, Beijing Daxing District Hospital, Capital MedicalUniversity,Beijing,China,3InstituteofMentalHealth,PekingUniversity,Beijing,China Abstract Background: Studies show that poststroke depression (PSD) increases mortality risk at 1 year. However, whether PSD increases the risk of recurrent stroke at 1 year remains unclear. This study was to investigate whether PSD at 2 weeks followingastrokecouldincreaseriskofrecurrentstrokeat1year. MethodsandResults:Thiswasamulti-centeredprospectivecohortstudy.Atotalof2306patientswithacutestrokewere enrolledinourstudy.PSDwasdiagnosedaccordingtothecriteriasetbytheDiagnosticandStatisticalManualofMental Disorders,fourthedition(DSM-IV).Theoutcomesofrecurrentstrokewerefollowedupviaface-to-faceorphoneinterview.A total of 1713 patients had complete follow-up data, with 481 (28.1%) cases of PSD and 158 (9.2%) cases of cumulative recurrentstrokeat1year.Multivariatelogisticregressionanalysisshoweda49%increaseofORofrecurrentstrokeat1year in patients with PSD, compared to patients without PSD following a stroke (OR=1.49, 95%CI: 1.03–2.15). There was no significantcorrelationbetweenanti-depressantdrugsandtheriskofrecurrentstrokeat1yearfollowingastroke(OR=1.96, 95%:CI0.95–4.04). Conclusions: Based on the DSM-IV diagnostic criteria, nearly 3 out of 10 hospitalized stroke patients in China were diagnosedwithPSDat2weeksfollowingastroke.PSDisassociatedwithahigherriskofrecurrentstrokeat1year.Our studydidnotfindbenefitofanti-depressantdrugsinreducingsuchrisk. Citation:YuanHW,WangCX,ZhangN,BaiY,ShiYZ,etal.(2012)PoststrokeDepressionandRiskofRecurrentStrokeat1YearinaChineseCohortStudy.PLoS ONE7(10):e46906.doi:1