Preventive and Therapeutic Strategies for Bovine Leukemia Virus Lessons for HTLV 英文参考文献.docVIP

Viruses 2011, 3, 1210-1248; doi:10.3390/v3071210 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV Sabrina M. Rodríguez 1, Arnaud Florins 2, Nicolas Gillet 1, Alix de Brogniez 2, María Teresa Sánchez-Alcaraz 2, Mathieu Boxus 2, Fanny Boulanger 1, Gerónimo Gutiérrez 3, Karina Trono 3, Irene Alvarez 3, Lucas Vagnoni 3 and Luc Willems 1,2,* 1 Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège (ULg), 4000, Liège, Belgium; E-Mails: Sabrina.Rodriguez@ulg.ac.be (S.M.R.); n.gillet@ulg.ac.be (N.G.); fanny.boulanger@hotmail.fr (F.B.) 2 Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Liège (ULg), 5030, Gembloux, Belgium; E-Mails: afflorins@ulg.ac.be (A.F.); Alix.deBrogniez@student.ulg.ac.be (A.d.B.); mteresasanchez@ (M.T.S.-A.); Mathieu.Boxus@ulg.ac.be (M.B.) 3 Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina; E-Mails: ggutierrez@.ar (G.G.); ktrono@.ar (K.T.); ialvarez@.ar (I.A.); lvagnoni@.ar (L.V.) * Author to whom correspondence should be addressed; E-Mail: luc.willems@ulg.ac.be; Tel.: +32-(0)-4-3662978; or +32-(0)-81-622157; Fax: +32-(0)-81-613888. Received: 21 May 2011; in revised form: 28 June 2011 / Accepted: 29 June 2011 / Published: 19 July 2011 Abstract: Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions