Prognostic value of brain natriuretic peptide in acute pulmonary embolism 英文参考文献.docVIP

Available online /content/12/4/R109 Research Open Access Vol 12 No 4 Prognostic value of brain natriuretic peptide in acute pulmonary embolism Guillaume Coutance1, Olivier Le Page2, Ted Lo1 and Martial Hamon1,3 1Service des Maladies du Coeur et des Vaisseaux, UF Soins Intensifs Cardiologiques, Centre Hospitalier Universitaire de Caen, Avenue C?te de Nacre, 14033 Caen Cedex, Normandy, France 2Service de Chirurgie Cardiaque, Centre Hospitalier Universitaire de Caen, Avenue C?te de Nacre, 14033 Caen Cedex, Normandy, France 3Inserm 744, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille cedex, France Corresponding author: Martial Hamon, hamon-m@chu-caen.fr Received: 10 Jun 2008 Revisions requested: 8 Jul 2008 Revisions received: 6 Aug 2008 Accepted: 22 Aug 2008 Published: 22 Aug 2008 Critical Care 2008, 12:R109 (doi:10.1186/cc6996) This article is online at: /content/12/4/R109 ? 2008 Coutance et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The relationship between brain natriuretic peptide (BNP) increase in acute pulmonary embolism (PE) and the increase in mortality and morbidity has frequently been studies involving a total of 868 patients with acute PE at baseline were included in the meta-analysis using a random- effects model. suggested in small studies but its global prognostic performance remains largely undefined. We performed a systematic review and meta-analysis of data to examine the prognostic value of elevated BNP for short-term all-cause mortality and serious adverse events. Results Elevated BNP levels were significantly associated with short-term all-cause mortality (odds ratio [OR] 6.57, 9