Production of Salvianolic Acid B in Roots of Salvia miltiorrhiza (Danshen) During the Post-Harvest Drying Process 英文参考文献.docVIP

Molecules 2012, 17, 2388-2407; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Production of Salvianolic Acid B in Roots of Salvia miltiorrhiza (Danshen) During the Post-Harvest Drying Process Xiao-Bing Li 1,2,?, Wei Wang 1,2,?, Guo-Jun Zhou 1, Yan Li 1, Xiao-Mei Xie 2 and Tong-Shui Zhou 1,* 1 Research Center of Natural Products, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, Fudan University, Shanghai 200433, China 2 School of Traditional Chinese Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei 230038, China; E-Mail: xiexiaomei9401@ (X.-M.X.) ? These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: tszhou@; Tel. +86-021-65642-206; Fax: +86-021-6564-2206. Received: 13 January 2012; in revised form: 7 February 2012 / Accepted: 14 February 2012 / Published: 27 February 2012 Abstract: Drying is the most common and fundamental procedure in the post-harvest processing which contributes to the quality and valuation of medicinal plants. However, attention to and research work on this aspect is relatively poor. In this paper, we reveal dynamic variations of concentrations of five major bioactive components, namely salvianolic acid B (SaB), dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA, in roots of Salvia miltiorrhiza (Dashen) during the drying process at different oven temperatures. A minor amount of SaB was found in fresh materials while an noticeable increase in SaB was detected in drying at 50~160 °C. The maximal value occured after 40 min of drying at 130 °C and its variation showed a reverse V-shaped curve. Production of SaB exhibited a significant positive correlation with drying temperatures and a significant negative correlation with sample moistures. The amounts of t