Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation 英文参考文献.docVIP

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Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation 英文参考文献.doc

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Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation 英文参考文献

ProbioticsModulateIntestinalExpressionofNuclear ReceptorandProvideCounter-RegulatorySignalsto Inflammation-DrivenAdiposeTissueActivation AndreaMencarelli1,EleonoraDistrutti2,BarbaraRenga1,ClaudioD’Amore1,SabrinaCipriani1 ,Giuseppe Palladino1,AnnibaleDonini3,PatriziaRicci3,StefanoFiorucci1* 1DipartimentodiMedicinaClinicaeSperimentale,UniversityofPerugia,Facolta` diMedicinaeChirurgia,ViaGerardoDottorinu1S.AndreadelleFratte,Perugia,Italy, 2AziendaOspedalieradiPerugia,OspedaleSantaMariadellaMisericordia,S.AndreadelleFratte,Perugia,Italy,3DipartimentodiScienzeChirurgiche,Radiologichee Odontostomatologiche,NuovaFacolta` diMedicinaeChirurgiaSant’AndreadelleFratte,Perugia,Italy Abstract Background: Adipocytes from mesenteric white adipose tissue amplify the inflammatory response and participate in inflammation-driven immune dysfunction in Crohn’s disease by releasing proinflammatory mediators. Peroxisome proliferator-activatedreceptors(PPAR)-aand-c,pregnanexreceptor(PXR),farnesoidxreceptor(FXR)andliverx-receptor (LXR) are ligand-activated nuclear receptor that provide counter-regulatory signals to dysregulated immunity and modulatesadiposetissue. Aims:Toinvestigatetheexpressionandfunctionofnuclearreceptorsinintestinalandadiposetissuesinarodentmodelof colitisandmesentericfatfromCrohn’spatientsandtoinvestigatetheirmodulationbyprobiotics. Methods: Colitis was induced by TNBS administration. Mice were administered vehicle or VSL#3, daily for 10 days. Abdominal fat explants obtained at surgery from five Crohn’s disease patients and five patients with colon cancer were culturedwithVSL# 3medium. Results:Probioticadministrationattenuateddevelopmentofsignsandsymptomsofcolitis,reducedcolonicexpressionof TNFa,IL-6andIFNcandreservedcolonicdownregulationofPPARc,PXRandFXRcausedbyTNBS.Mesentericfatdepots isolatedfromTNBS-treatedanimalshadincreasedexpressionofinflammatorymediatorsalongwithPPARc,FXR,leptinand adiponectin.ThesechangeswerepreventedbyVSL#3.Creepingfatandmesentericadip