Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats 英文参考文献.docVIP

Molecules 2012, 17, 3805-3817; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats Li Zhang, Jiangwei Ma * and Huajin Liu Department of Cardiology, Fengxian Branch of Shanghai 6th People’s Hospital, Shanghai 201400, China * Author to whom correspondence should be addressed; E-Mail: jwma3051@163.com; Tel.: +86-137-7429-0588; Fax: +86-021-5741-2833. Received: 13 March 2012; in revised form: 22 March 2012 / Accepted: 23 March 2012 / Published: 27 March 2012 Abstract: Brief episodes of myocardial ischemia-reperfusion (IR) employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of ischemic postconditioning on an ischemic reperfusion (IR)-induced myocardium oxidative injury in rat model. Results showed that ischemic postconditioning could improve arrhythmia cordis, reduce myocardium infarction and serum creatin kinase (CK), lactate dehydrogenase (LDH) and aspartate transaminase (AST) activities in IR rats. In addition, ischemic postconditioning could still decrease myocardium malondialdehyde (MDA) level, and increased myocardium Na+-K+-ATPase, Ca2+-Mg2+-ATPase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) activities. It can be concluded that ischemic postconditioning possesses strong protective effects against ischemia reperfusion-induced myocardium oxidative injury in IR rats. Keywords: ischemia-reperfusion; ischemic postconditioning; myocardium; oxidative injury 1. Introduction Despite the powerful protective effects of ischemic preconditioning, the clinical application of this phenomenon has