Protective Effect of Polyphenols Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia-Induced Oxidative Stress in Rats 英文参考文献.docVIP

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Protective Effect of Polyphenols Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia-Induced Oxidative Stress in Rats 英文参考文献.doc

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Protective Effect of Polyphenols Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia-Induced Oxidative Stress in Rats 英文参考文献

Molecules 2012, 17, 8886-8897; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Protective Effect of Polyphenols Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia-Induced Oxidative Stress in Rats Lifeng Wang 1,2, Jing Sun 3, Qida Yi 2, Xuefeng Wang 2 and Xingrong Ju 1,2,* 1 School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 24122, China; E-Mail: wanglifeng_8@163.com 2 School of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, Jiangsu 210046, China; E-Mails: yi.qida@ (Q.Y.); wangxuefeng2870@126.com (X.W.) 3 Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; E-Mail: sjing324@ * Author to whom correspondence should be addressed; E-Mail: xingrongju@163.com; Tel./Fax: +86-25-8402-8788. Received: 11 June 2012; in revised form: 15 July 2012 / Accepted: 21 July 2012 / Published: 26 July 2012 Abstract: The present study examines the effect of polyphenols extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) (APE) on high cholesterol diet fed rats (HCD). APE was orally administrated by gavage at doses of 10, 40 and 200 mg total phenolics/kg body weight of rats once a day for 28 days. At the end of four weeks, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), and markers of oxidative stress viz., malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the serum and liver of HCD and normal rats were assessed and compared. The results showed that administration of APE was significantly effective in decreasing the serum levels of TC, LDL-C and MDA, increasing the serum level of HDL-C and antioxidant capacity. In addition, oral gavage of