Protocadherin-18 Is a Novel Differentiation Marker and an Inhibitory Signaling Receptor for CD8+ Effector Memory T Cells 英文参考文献.docVIP

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Protocadherin-18 Is a Novel Differentiation Marker and an Inhibitory Signaling Receptor for CD8+ Effector Memory T Cells 英文参考文献.doc

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Protocadherin-18IsaNovelDifferentiationMarkerandanInhibitorySignalingReceptorforCD8EffectorMemoryTCells英文参考文献

Protocadherin-18IsaNovelDifferentiationMarkerand anInhibitorySignalingReceptorforCD8 Effector MemoryTCells + EdwinJ.Vazquez-Cintron1,NgoziR.Monu2,JeremyC.Burns1,RoyBlum2,GregoryChen1,PeterLopez3, JenniferMa4,SasaRadoja4,AlanB.Frey1,2* 1DepartmentofCellBiology,NewYorkUniversityLangoneSchoolofMedicineNewYork,NewYork,UnitedStatesofAmerica,2NewYorkUniversityCancerInstitute, NewYorkUniversityLangoneSchoolofMedicineNewYork,NewYork,UnitedStatesofAmerica,3DepartmentofPathology,NewYorkUniversityLangoneSchoolof Medicine New York, New York, United States of America, 4Center for Cancer and Immunology Research, Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’sResearchInstitute,Children’sNationalMedicalCenter,Washington,DistrictofColumbia,UnitedStatesofAmerica Abstract CD8+ tumor infiltrating T cells (TIL) lack effector-phase functions due to defective proximal TCR-mediated signaling previouslyshowntoresultfrominactivationofp56lckkinase.Weidentifyanovelinteractingpartnerforp56lckinnonlytic TIL,Protocadherin-18(‘pcdh18’),andshowthatpcdh18istranscribeduponinvitroorinvivoactivationofallCD8 central + memory T cells (CD44+CD62LhiCD127 ) coincident with conversion into effector memory cells (CD44+CD62LloCD127+). + + Expressionofpcdh18inprimaryCD8 effectorcellsinducesthephenotypeofnonlyticTIL:defectiveproximalTCRsignaling, cytokinesecretion,andcytolysis,andenhancedAICD.pcdh18containsamotif(centeredatY842)sharedwithsrckinases + (QGQYQP)thatisrequiredfortheinhibitoryphenotype.Thus,pcdh18isanovelactivationmarkerofCD8 memoryTcells thatcanfunctionasaninhibitorysignalingreceptorandrestricttheeffectorphase. Citation:Vazquez-CintronEJ,MonuNR,BurnsJC,BlumR,ChenG,etal.(2012)Protocadherin-18IsaNovelDifferentiationMarkerandanInhibitorySignaling ReceptorforCD8+EffectorMemoryTCells.PLoSONE7(5):e36101.doi:10.1371/journal.pone.0036101 Editor:JoaoP.B.Viola,NationalCancerInstitute(INCA),Brazil ReceivedFebruary22,2012;AcceptedMarch26,2012;PublishedMay2,2012 Copyr