Psoriatic arthritis synovial histopathology commentary on the article by Kruithof and colleagues 英文参考文献.docVIP

Arthritis Research Therapy June 2005 Vol 7 No 3 FitzGerald Commentary Psoriatic arthritis synovial histopathology: commentary on the article by Kruithof and colleagues Oliver FitzGerald Newman Clinical Research Professor, St Vincent’s University Hospital, Dublin, Ireland Corresponding author: Oliver FitzGerald, ofitzger@iol.ie Published: 18 April 2005 Arthritis Research Therapy 2005, 7:124-125 (DOI 10.1186/ar1747) This article is online at /content/7/3/124 ? 2005 BioMed Central Ltd See related research by Kruithof et al., /content/7/3/R569 Abstract Previous studies have compared PsA with RA [3], although Kruithof and colleagues’ study is the first to include other SpA patients in the comparison. In the previous study [3], an increase in vessel number was also a distinguishing feature from RA, as were lower macrophage numbers and a reduction in E-selectin expression. Kruithof and colleagues were unable to confirm these findings, which have been confirmed by others [4], but this may relate to issues of patient selection and to methods of quantification of cellular The clinical features in psoriatic arthritis straddle the divide between rheumatoid arthritis on the one hand and spondylo- arthropathy on the other. The paper by Kruithof and colleagues compares synovial immunohistologic features and clearly identifies psoriatic arthritis as being a member of the spondyloarthropathy family. The excellent article by Kruithof and colleagues stimulates many questions while carefully dissecting differentiating infiltration (semi-quantitative versus quantitative). The features rheumatoid arthritis (RA) and spondyloarthropathy (SpA), in particular quantitative scoring system, the authors identified a number of features characteristic of RA synovium, including the lining layer thickness, CD83+ dendritic cells, positive stai