Putative EPHX1 Enzyme Activity Is Related with Risk of Lung and Upper Aerodigestive Tract Cancers A Comprehensive Meta-Analysis 英文参考文献.docVIP

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Putative EPHX1 Enzyme Activity Is Related with Risk of Lung and Upper Aerodigestive Tract Cancers A Comprehensive Meta-Analysis 英文参考文献.doc

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Putative EPHX1 Enzyme Activity Is Related with Risk of Lung and Upper Aerodigestive Tract Cancers A Comprehensive Meta-Analysis 英文参考文献

PutativeEPHX1EnzymeActivityIsRelatedwithRiskof LungandUpperAerodigestiveTractCancers:A ComprehensiveMeta-Analysis XiangLi1.,ZhengHu2.,XinshunQu3,JiadongZhu1,LinLi1,BrianZ.Ring4,LiSu1* 1KeyLaboratory ofMolecularBiophysicsofMinistryofEducation,SchoolofLifeScienceandTechnology,Sino-FranceJointCenterforDrugResearchandScreening, Huazhong University of Science and Technology, Wuhan, China, 2Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, 3Department of Plant Pathology,ThePennsylvaniaStateUniversity,UniversityPark,Pennsylvania,UnitedStatesofAmerica,4YigeneInc,Jianwai,Beijing,China Abstract Background:EPHX1isakeyenzymeinmetabolizingsomeexogenouscarcinogenssuchasproductsofcigarette-smoking. TwofunctionalpolymorphismsintheEPHX1gene,Tyr113HisandHis139Argcanaltertheenzymeactivity,suggestingtheir possibleassociationwithcarcinogenesisrisk,particularlyofsometobacco-relatedcancers. Methodology/Principal Findings: A comprehensive systematic review and meta-analysis was performed of available studiesonthesetwopolymorphismsandcancerriskpublisheduptoNovember2010,consistingof84studies(31144cases and42439controls)forTyr113Hisand77studies(28496casesand38506controls)forHis139Argprimarilyfocusedonlung cancer,upperaerodigestivetract(UADT)cancers(includingoral,pharynx,larynxandesophaguscancers),colorectalcancer oradenoma,bladdercancerandbreastcancer.ResultsshowedthatY113Hlowactivityallele(H)wassignificantlyassociated with decreased risk of lung cancer (OR=0.88, 95%CI=0.80–0.96) and UADT cancers (OR=0.86, 95%CI=0.77–0.97) and H139R high activity allele (R) with increased risk of lung cancer (OR=1.18, 95%CI=1.04–1.33) but not of UADT cancers (OR=1.05, 95%CI=0.93–1.17). Pooled analysis of lung and UADT cancers revealed that low EPHX1 enzyme activity, predictedbythecombinationofY113HandH139Rshoweddecreasedriskofthesecancers(OR=0.83,95%CI=0.75–0.93) whereashighEPHX1activityincreasedriskofthecancers(OR=1.20,95%CI=0.98–1.46).Furthermore,modestdifferencefor theriskoflun