Pulmonary Function and Incident Bronchitis and Asthma in Children A Community-Based Prospective Cohort Study 英文参考文献.docVIP

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Pulmonary Function and Incident Bronchitis and Asthma in Children A Community-Based Prospective Cohort Study 英文参考文献.doc

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Pulmonary Function and Incident Bronchitis and Asthma in Children A Community-Based Prospective Cohort Study 英文参考文献

PulmonaryFunctionandIncidentBronchitisandAsthma inChildren:ACommunity-BasedProspectiveCohort Study YunglingLeoLee1,2*,Bing-FangHwang3,Yu-AnChen1,Jer-MinChen1,4,Yi-FanWu1,4 1InstituteofEpidemiologyandPreventiveMedicine,CollegeofPublicHealth,NationalTaiwanUniversity,Taipei,Taiwan,2DepartmentofPublicHealth,CollegeofPublic Health,NationalTaiwanUniversity,Taipei,Taiwan,3DepartmentofOccupationalSafetyandHealth,CollegeofPublicHealth,ChinaMedicalUniversity,Taichung,Taiwan, 4DepartmentofFamilyMedicine,TaipeiCityHospital,RenaiBranch,Taipei,Taiwan Abstract Background:Previousstudiesrevealedthatreductionofairwaycaliberininfancymightincreasetherisksforwheezingand asthma.However,theevidenceforthepredictiveeffectsofpulmonaryfunctiononrespiratoryhealthinchildrenwasstill inconsistent. Methods:Weconductedapopulation-basedprospectivecohortstudyamongchildrenin14Taiwanesecommunities.There were3,160childrencompletedpulmonaryfunctiontestsin2007andfollow-upquestionnairein2009.Poissonregression modelswereperformedtoestimatetheeffectofpulmonaryfunctiononthedevelopmentofbronchitisandasthma. Results:Afteradjustmentforpotentialconfounders,pulmonaryfunctionindicesconsistentlyshowedprotectiveeffectson respiratorydiseasesinchildren.Theincidencerateratiosofbronchitisandasthmawere0.86(95%CI0.79–0.95)and0.91 (95%CI0.82–0.99)forforcedexpiratoryvolumein1second(FEV1).Similaradverseeffectsofmaximalmid-expiratoryflow (MMEF)werealsoobservedonbronchitis(RR=0.73,95%CI0.67–0.81)andasthma(RR=0.85,95%CI0.77–0.93).Wefound significantdecreasingtrendsincategorizedFEV1(pfortrend=0.02)andcategoriesofMMEF(pfortrend=0.01)forincident bronchitis.Significantmodificationeffectsoftraffic-relatedairpollutionwerenotedforFEV1andMMEFonbronchitisand alsoforMMEFonasthma. Conclusions:Childrenwithhighpulmonaryfunctionwouldhavelowerrisksonthedevelopmentofbronchitisandasthma. Theprotectiveeffectofhighpulmonaryfunctionwouldbemodifiedbytraffic-relatedairpollutionexposure. Citation: Lee YL, Hwang B-F, Chen Y-A, Chen J-M, Wu Y-F (2012)