Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis 英文参考文献.docVIP

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Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis 英文参考文献.doc

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Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis 英文参考文献

Available online /content/7/6/R1404 Research article Open Access Vol 7 No 6 Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis En-Pei I Chiang1, Jacob Selhub2, Pamela J Bagley2, Gerard Dallal3 and Ronenn Roubenoff4,5 1Department of Food Science and Biotechnology, National Chung-Hsing University, 250 Kuo-Kuang Road, Taichung, Taiwan 402, Republic of China 2Vitamin Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA 3Biostatistics Unit, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA 4Nutrition, Exercise Physiology, and Sarcopenia Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA 5Tufts-New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA Corresponding author: En-Pei I Chiang, chiangisabel@.tw Received: 16 Jun 2005 Revisions requested: 9 Aug 2005 Revisions received: 6 Sep 2005 Accepted: 14 Sep 2005 Published: 14 Oct 2005 Arthritis Research Therapy 2005, 7:R1404-R1411 (DOI 10.1186/ar1839) This article is online at: /content/7/6/R1404 ? 2005 Chiang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License /licenses/by/2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Patients with rheumatoid arthritis have subnormal vitamin B6 status, both quantitatively and functionally. Abnormal vitamin B6 status in rheumatoid arthritis has been associated with spontaneous tumor necrosis factor (TNF)-α production and markers of inflammation, including C-reactive protein and erythrocyte sedimentation rate. Impaired vitamin B6 status c