Quantifying the Importance of Interleukin-6 for Coronary Heart Disease 英文参考文献.docVIP

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Quantifying the Importance of Interleukin-6 for Coronary Heart Disease 英文参考文献.doc

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Quantifying the Importance of Interleukin-6 for Coronary Heart Disease 英文参考文献

Perspective Quantifying the Importance of Interleukin-6 for Coronary Heart Disease Bruce Neal F or many years it was widely believed that known vascular risk factors could explain only Linked Research Article measurement of blood pressure was shown to substantially underestimate the strength of the association with both stroke and heart attack [3]. Since those ?rst reports, a number of approaches have been developed to control for “regression dilution bias” [6]. The associations of IL-6 with coronary heart disease reported by Danesh and colleagues were adjusted using an established technique based upon repeated assays of IL-6 done several years apart in a sample of participants. Adjustments for errors in exposure measurement were also made for the covariates included in the multivariable models ?tted to the data from the Reykjavik and BRHS studies, providing for uniquely powerful adjustment of potential confounders of the association of IL-6 with CHD. As such, the results provide a particularly reliable estimate of the strength of the association of IL-6 with CHD and establish a standard against which future studies of association might be judged. This Perspective discusses the following new study published in PLoS Medicine: Danesh J, Kaptoge S, Mann AG, Sarwar N, Wood A, et al. (2008) Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review. PLoS Med 5(4): e78. doi:10.1371/ journal.pmed.0050078 John Danesh and colleagues show that long-term IL-6 levels are associated with coronary heart disease risk, thus highlighting the potential relevance of IL- 6–mediated pathways to coronary heart disease. about half of all cardiovascular disease [1], leaving much to be discovered about other causes of stroke and heart attack. There has been considerable interest in the possible aetiological role of in?ammation in vascular disease. Interleukin-6 (IL-6) is one of a number of in?ammatory markers that hav