Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit a randomized, double-blind controlled trial [ISRCTN43755713] 英文参考文献.docVIP

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Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit a randomized, double-blind controlled trial [ISRCTN43755713] 英文参考文献.doc

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Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit a randomized, double-blind controlled trial [ISRCTN43755713] 英文参考文献

Available online /content/8/1/R1 Open Access Research Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit: a randomized, double-blind controlled trial [ISRCT Bernd Muellejans1, Angel López2, Michael H Cross3, César Bonome4, Lachlan Morrison5 and Andrew JT Kirkham6 1Director of Anaesthesiology Intensive Care Medicine, Klinikum Karlsburg, Herz-und Diabeteszentrum Mecklenburg-Vorpommern Klinik für Anaesthesiologie und Intensivmedizin, Karlsburg, Germany 2Consultant Anaesthesiologist, Servicio de Medicina Intensiva, Hospital Universitario Infanta Cristina, Badajoz, Spain 3Consultant Anaesthetist, Department of Anaesthesia, Leeds General Infirmary, Leeds, UK 4Attending Staff, Department of Anaesthesiology, Hospital Juan Canalejo, Servicio de Anestesiologia y Reanimación, La Coru?a, Spain 5Consultant in Anaesthetics and Intensive Care, Department of Anaesthesia, St. John’s Hospital, Livingston, UK 6Global Study Manager, GlaxoSmithKline Research and Development, Greenford, UK Correspondence: Bernd Muellejans, dr.muellejans@drguth.de Received: 2 October 2003 Accepted: 16 October 2003 Published: 20 November 2003 Critical Care 2004, 8:R1-R11 (DOI 10.1186/cc2398) This article is online at /content/8/1/R1 ? 2004 Muellejans et al., licensee BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X). This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Introduction This double-blind, randomized, multicentre study was conducted to compare the efficacy and safety of remifentanil and fentanyl for intensive care unit (ICU) sedation and analgesia. Methods Intubated cardiac, general postsurgical or medical patients (aged ≥18 years), who were mechanically ventilated for 12–72 hours, received remifentanil (9μg/kg per hour; n = 77) or fentanyl (1.