Rethinking Outreach Teaching the Process of Science through Modeling 英文参考文献.docVIP

Rethinking Outreach Teaching the Process of Science through Modeling 英文参考文献.doc

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Rethinking Outreach Teaching the Process of Science through Modeling 英文参考文献

Community Page Rethinking Outreach: Teaching the Process of Science through Modeling Tim Herman , Shannon Colton, Margaret Franzen * “O from an arginine to an h,…you mean if you want to change the amino acid alanine, you just change the code in that position.” This “aha moment” recently happened for a member of the Brown Deer High School SMART (Students Modeling a Research Topic) Team at a Saturday morning meeting while awaiting the arrival of their scientist mentor. This student had just realized that the process used by scientists to create modi?ed proteins, and to test the impact of that modi?cation on function, involves engineering the gene for the protein, and then expressing the modi?ed gene in an appropriate system. The excitement of this new insight spread throughout the team as other students picked up this new information and began to reinterpret some elements of “the story” that had been told to them by their scientist mentor at a previous meeting. Their mentor’s story about the tumor suppressor maspin and its role in metastasis was now becoming “their story”—as they began to truly understand not only what the maspin protein was and how it functioned, but also the process of science whereby their mentor had designed an experiment that resulted in the data that supported the story. And the story was becoming all the more compelling because the students had in hand a physical model of the maspin protein they had designed and built using rapid prototyping technology (see Figure 1). There has been a recent call for undergraduate faculty to engage in “scienti?c teaching”—a way of active teaching that places equal emphasis on both the process of science and the facts of science [1]. We endorse this approach and believe that the Milwaukee School of Engineering (MSOE) SMART Team modeling program captures many of the doi:10.1371/journal.pbio.0060086.g001 Figure 1. Creating the “Aha” Moment Members of the Brown Deer High School SMART Team examine the alanine-to-

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