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Rethinking Outreach Teaching the Process of Science through Modeling 英文参考文献
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Rethinking Outreach: Teaching the Process
of Science through Modeling
Tim Herman , Shannon Colton, Margaret Franzen
*
“O from an arginine to an
h,…you mean if you want
to change the amino acid
alanine, you just change the code in that
position.” This “aha moment” recently
happened for a member of the Brown
Deer High School SMART (Students
Modeling a Research Topic) Team
at a Saturday morning meeting while
awaiting the arrival of their scientist
mentor. This student had just realized
that the process used by scientists to
create modi?ed proteins, and to test
the impact of that modi?cation on
function, involves engineering the gene
for the protein, and then expressing the
modi?ed gene in an appropriate system.
The excitement of this new insight
spread throughout the team as other
students picked up this new information
and began to reinterpret some elements
of “the story” that had been told to
them by their scientist mentor at a
previous meeting. Their mentor’s story
about the tumor suppressor maspin and
its role in metastasis was now becoming
“their story”—as they began to truly
understand not only what the maspin
protein was and how it functioned,
but also the process of science
whereby their mentor had designed an
experiment that resulted in the data
that supported the story. And the story
was becoming all the more compelling
because the students had in hand a
physical model of the maspin protein
they had designed and built using rapid
prototyping technology (see Figure 1).
There has been a recent call for
undergraduate faculty to engage in
“scienti?c teaching”—a way of active
teaching that places equal emphasis
on both the process of science and
the facts of science [1]. We endorse
this approach and believe that the
Milwaukee School of Engineering
(MSOE) SMART Team modeling
program captures many of the
doi:10.1371/journal.pbio.0060086.g001
Figure 1. Creating the “Aha” Moment
Members of the Brown Deer High School SMART Team examine the alanine-to-
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