Role of nitric oxide in the gastrointestinal tract 英文参考文献.docVIP

Available online /supplements/10/S2/S4 Review Role of nitric oxide in the gastrointestinal tract Angel Lanas Servicio de Aparato Digestivo, Hospital Clinico Zaragoza, CIBERehd, IACS, Universidad de Zaragoza, C/ Domingo Miral s/n, 50009 Zaragoza, Spain Corresponding author: Angel Lanas, angel.lanas@ Published: 17 October 2008 Arthritis Research Therapy 2008, 10(Suppl 2):S4 (doi:10.1186/ar2465) This article is online at /supplements/10/S2/S4 ? 2008 BioMed Central Ltd Abstract The search for new agents with which to manage pain and to reduce the attendant adverse events associated with NSAID use has led to the development of a new class of agents termed cyclo-oxygenase (COX)-inhibiting, nitric oxide (NO)- donating drugs (CINODs). CINODs are NO donors in which NO is coupled to an NSAID and could potentially improve the gastrointestinal safety profile of traditional NSAIDs [6,7]. This review discusses the known functions of NO in the gastro- intestinal tract and some of the mechanisms that underlie NSAID-induced gastric damage. The potential benefits of NO-donating agents in the treatment of NSAID-induced gastric damage are reviewed, and finally the potential benefits of CINODs in the management of OA are discussed. Worldwide osteoarthritis (OA) affects more than 9.6% of men and 18% of women older that 60 years. Treatment for OA often requires chronic use of selective or nonselective nonsteroidal anti- inflammatory drugs (NSAIDs), which have been associated with gastrointestinal and cardiovascular complications. An increased risk for upper gastrointestinal bleeding with NSAIDs alone and when combined with low-dose aspirin has been described in numerous studies. Although cyclo-oxygenase-2 inhibitors have been shown to carry a lower risk for gastrointestinal injury than nonselective NSAIDs, research continues to identify new treatments that not only are