Risk for Asthma in Offspring of Asthmatic Mothers versus Fathers A Meta-Analysis 英文参考文献.docVIP

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Risk for Asthma in Offspring of Asthmatic Mothers versus Fathers A Meta-Analysis 英文参考文献.doc

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Risk for Asthma in Offspring of Asthmatic Mothers versus Fathers A Meta-Analysis 英文参考文献

RiskforAsthmainOffspringofAsthmaticMothersversus Fathers:AMeta-Analysis RobertH.Lim1,3,LesterKobzik1,4,MortenDahl2* 1Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America, 2Department of Clinical Biochemistry, CopenhagenUniversityHospitalHerlev,Copenhagen,Denmark,3DepartmentofPulmonaryMedicine,Children’sHospitalBoston,Boston,Massachusetts,UnitedStates ofAmerica,4DepartmentofPathology,BrighamandWomen’sHospital,Boston,Massachusetts,UnitedStatesofAmerica Abstract Background: Many human epidemiologic studies demonstrate that maternal asthma confers greater risk of asthma to offspringthandoespaternaldisease.However,ahandfulhaveshowntheopposite.Giventhisdisparity,ameta-analysisis necessarytodeterminetheveracityandmagnitudeofthe‘‘maternaleffect.’’ Methodology/PrincipalFindings:Wescreenedthemedicalliteraturefrom1966to2009andperformedameta-analysisto comparetheeffectofmaternalasthmavs.paternalasthmaonoffspringasthmasusceptibility.Aggregatingdatafrom33 studies,theoddsratioforasthmainchildrenofasthmaticmotherscomparedwithnon-asthmaticmotherswassignificantly increased at3.04(95%confidence interval:2.59–3.56). Thecorrespondingodds ratioforasthma inchildren ofasthmatic fathers was increased at 2.44 (2.14–2.79). When comparing the odds ratios, maternal asthma conferred greater risk of diseasethandidpaternalasthma(3.04vs.2.44,p=0.037).Whenanalyzingthestudiesinwhichasthmawasdiagnosedbya physician the odds ratios were attenuated and no significant differences were observed (2.85 vs. 2.48, N=18, p=0.37). Similarly,nosignificantdifferenceswereobservedbetweenmaternalandpaternaloddsratioswhenanalyzingthestudiesin which the patientpopulation was 5 years or older (3.15 vs. 2.60, p=0.14). However, in all cases the trendremained the same,thatmaternalasthmawasagreaterriskfactorforasthmathanpaternal. Conclusions/Significance:Theresultsshowthatmaternalasthmaincreasesoffspringdiseaserisktoagreaterextentthan paternaldisease. Cita