Risk of Cardiovascular Disease in a Traditional African Population with a High Infectious Load A Population-Based Study 英文参考文献.docVIP

RiskofCardiovascularDiseaseinaTraditionalAfrican PopulationwithaHighInfectiousLoad:APopulation- BasedStudy Jacob J. E. Koopman1*, David van Bodegom2,5 , 3 J. Wouter Jukema , Rudi G. J. Westendorp4,5,1 1 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, 2 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, 3 Department of Cardiology, Leiden University Medical 4 Department oThe f GerontologNetherlands, y and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, 5 Leyden Academy on Vitality and Ageing, Leiden, The Netherlands Center, Leiden, Abstract Background: To test the inflammatory origin of cardiovascular disease, as opposed to its origin in western lifestyle. Population-based assessment of the prevalences of cardiovascular risk factors and cardiovascular disease in an inflammation-prone African population, including electrocardiography and ankle-arm index measurement. Comparison with known prevalences in American and European societies. Methodology/PrincipalFindings: Traditional population in rural Ghana, characterised by adverse environmental conditions and a high infectious load. Population-based sample of 924 individuals aged 50 years and older. Median values for cardiovascular risk factors, including waist circumference, BMI, blood pressure, and markers of glucose and lipid metabolism and inflammation. Prevalence of myocardial infarction detected by electrocardiography and prevalence of peripheral arterial disease detected by ankle-arm index. When compared to western societies, we found the Ghanaians to have more proinflammatory profiles and less cardiovascular risk factors, including obesity, dysglycaemia, dyslipidaemia, and hypertension. Prevalences o