Risk of Hormone Escape in a Human Prostate Cancer Model Depends on Therapy Modalities and Can Be Reduced by Tyrosine Kinase Inhibitors 英文参考文献.docVIP

下载本文档

5
0
约4.07万字
约 10页
2017-05-13 发布于上海
举报
版权申诉

Risk of Hormone Escape in a Human Prostate Cancer Model Depends on Therapy Modalities and Can Be Reduced by Tyrosine Kinase Inhibitors 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Risk of Hormone Escape in a Human Prostate Cancer Model Depends on Therapy Modalities and Can Be Reduced by Tyrosine Kinase Inhibitors 英文参考文献

RiskofHormoneEscapeinaHumanProstateCancer ModelDependsonTherapyModalitiesandCanBe ReducedbyTyrosineKinaseInhibitors CharlotteGuyader1,JocelynCe′raline2,Ele′onoreGravier1,3,4,5,Aure′lieMorin6,SandrineMichel7, EvaErdmann2,GonzaguedePinieux8,FlorenceCabon6,Jean-PierreBergerat2,Marie-FrancePoupon1, Ste′phaneOudard9,10 * 1Translational Research Department, Institut Curie, Paris, France, 2Signaling and Prostate Cancer Group, Universite′ de Strasbourg, Strasbourg, France, 3Biostatistics Department,InstitutCurie,Paris,France,4U900,INSERM,Paris,France,5EcoledesMinesdeParis,ParisTech,Fontainebleau,France,6FRE2944,CNRS,Villejuif,France, 7BiomarkerResearchandValidationDepartment,BioMe′rieux, Marcyl’Etoile,France,8AnatomieetCytologiePathologiques,Ho?pitalTrousseau,Tours,France,9Medical Oncology,Ho?pitalEurope′enGeorgesPompidou,Paris,France,10Universite′ ParisVRene′ Descartes,Paris,France Abstract Almostallprostatecancersrespondtoandrogendeprivationtreatmentbutmanyrecur.Wepostulatedthatriskofhormone escape -frequency and delay- are influenced by hormone therapy modalities. More, hormone therapies induce crucial biological changes involving androgen receptors; some might be targets for escape prevention. We investigated the relationship between the androgen deprivation treatment and the risk of recurrence using nude mice bearing the high grade,hormone-dependent humanprostatecancer xenograftPAC120. Tumor-bearingmiceweretreatedbyLuteinizing- HormoneReleasingHormone(LHRH)antagonistalone,continuousorintermittentregimen,orcombinedwithandrogen receptor(AR)antagonists(bicalutamideorflutamide).Tumorgrowthwasmonitored.Biologicalchangeswerestudiedasfor genomic alterations, AR mutations and protein expression in a large series of recurrent tumors according to hormone therapymodalities.TherapiestargetingHer-2orAKTweretestedincombinationwithcastration.Allstatisticaltestswere two-sided.TumorgrowthwasinhibitedbycontinuousadministrationoftheLH-RHantagonistdegarelix(castration),but 40% o