RIC-7 Promotes Neuropeptide Secretion 英文参考文献.docVIP

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RIC-7 Promotes Neuropeptide Secretion 英文参考文献.doc

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RIC-7 Promotes Neuropeptide Secretion 英文参考文献

RIC-7PromotesNeuropeptideSecretion YingsongHao1,2,ZhitaoHu1,2,DerekSieburth3,JoshuaM.Kaplan1,2* 1DepartmentofMolecularBiology,MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesofAmerica,2DepartmentofNeurobiology,HarvardMedical School, Boston, Massachusetts, United States of America, 3Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, United States of America Abstract Secretion of neurotransmitters and neuropeptides is mediated by exocytosis of distinct secretory organelles, synaptic vesicles(SVs)anddensecorevesicles(DCVs)respectively.Relativelylittleisknownaboutfactorsthatdifferentiallyregulate SVandDCVsecretion.HereweidentifyanovelproteinRIC-7thatisrequiredforneuropeptidesecretioninCaenorhabditis elegans.TheRIC-7proteinisexpressedinallneuronsandislocalizedtopresynapticterminals.Imaging,electrophysiology, andbehavioralanalysisofric-7mutantsindicatesthatacetylcholinereleaseoccursnormally,whileneuropeptidereleaseis significantlydecreased.TheseresultssuggestthatRIC-7promotesDCV–mediatedsecretion. Citation:HaoY,HuZ,SieburthD,KaplanJM(2012)RIC-7PromotesNeuropeptideSecretion.PLoSGenet8(1):e1002464.doi:10.1371/journal.pgen.1002464 Editor:AndrewD.Chisholm,UniversityofCaliforniaSanDiego,UnitedStatesofAmerica ReceivedJuly8,2011;AcceptedNovember18,2011;PublishedJanuary19,2012 Copyright:?2012Haoetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: Thiswork wassupportedbyNIHresearch grantDK80215 (JMK).Thefunders hadnorole instudydesign, datacollectionandanalysis, decision to publish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:kaplan@ Introduction implying that CAPS is also required for SV priming. Similarly, some studies propose that Munc13 primes SVs but not DCVs [18],whileothersfindMunc13mut