Role of Peptidergic Nerve Terminals in the Skin Reversal of Thermal Sensation by Calcitonin Gene-Related Peptide in TRPV1-Depleted Neuropathy 英文参考文献.docVIP

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Role of Peptidergic Nerve Terminals in the Skin Reversal of Thermal Sensation by Calcitonin Gene-Related Peptide in TRPV1-Depleted Neuropathy 英文参考文献.doc

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Role of Peptidergic Nerve Terminals in the Skin Reversal of Thermal Sensation by Calcitonin Gene-Related Peptide in TRPV1-Depleted Neuropathy 英文参考文献

RoleofPeptidergicNerveTerminalsintheSkin:Reversal ofThermalSensationbyCalcitoninGene-Related PeptideinTRPV1-DepletedNeuropathy Yu-LinHsieh1,2.,Chih-LungLin3,4.,HaoChiang2,Yaw-SyanFu5,June-HorngLue2 ,Sung- TsangHsieh2,6,7 * 1Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 2Department of Anatomy and Cell Biology, CollegeofMedicine,NationalTaiwanUniversity,Taipei,Taiwan,3DepartmentofNeurosurgery,KaohsiungMedicalUniversityHospital,Kaohsiung,Taiwan,4Facultyof Medicine,GraduateInstituteofMedicine,CollegeofMedicine,KaohsiungMedicalUniversity,Kaohsiung,Taiwan,5DepartmentofBiomedicalScienceandEnvironmental Biology,CollegeofScience,KaohsiungMedicalUniversity,Kaohsiung,Taiwan,6DepartmentofNeurology,NationalTaiwanUniversityHospital,Taipei,Taiwan,7Graduate InstituteofBrainandMindSciences,CollegeofMedicine,NationalTaiwanUniversity,Taipei,Taiwan Abstract Toinvestigatethecontributionofpeptidergicintraepidermalnervefibers(IENFs)tonociceptiveresponsesafterdepletionof the thermal-sensitive receptor, transient receptor potential vanilloid subtype 1 (TRPV1), we took advantage of aresiniferatoxin(RTX)-inducedneuropathywhichspecificallyaffectedsmall-diameterdorsalrootganglion(DRG)neurons andtheircorrespondingnerveterminalsintheskin.Thermalhypoalgesia(p,0.001)developedfromRTX-treatmentday7 (RTXd7) and became normalized from RTXd56 to RTXd84. Substance P (SP)(+) and TRPV1(+) neurons were completely depleted(p=0.0001andp,0.0001,respectively),butRTXhadarelativelyminoreffectoncalcitoningene-relatedpeptide (CGRP)(+)neurons(p=0.029).Accordingly,SP(+)(p,0.0001)andTRPV1(+)(p=0.0008)IENFswerepermanentlydepleted, butCGRP(+)IENFs(p=0.012)wereonlytransientlyreducedandhadrecoveredbyRTXd84(p=0.83).Thedifferenteffectsof RTXonpeptidergicneuronswereattributedtothehigherco-localizationratioofTRPV1/SPthanofTRPV1/CGRP(p =0.029). Thermal hypoalgesia (p=0.0018) reappeared with an intraplantar injection of botulinum toxin type A (botox), and th