Rotating Night Shift Work and Risk of Type 2 Diabetes Two Prospective Cohort Studies in Women 英文参考文献.docVIP

下载本文档

16
0
约4.31万字
约 8页
2017-05-13 发布于上海
举报
版权申诉

Rotating Night Shift Work and Risk of Type 2 Diabetes Two Prospective Cohort Studies in Women 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Rotating Night Shift Work and Risk of Type 2 Diabetes Two Prospective Cohort Studies in Women 英文参考文献

RotatingNightShiftWorkandRiskofType2Diabetes: TwoProspectiveCohortStudiesinWomen AnPan1,EvaS.Schernhammer2,3,QiSun1,3,FrankB.Hu1,2,3 * 1DepartmentofNutrition,HarvardSchoolofPublicHealth,Boston,Massachusetts,UnitedStatesofAmerica,2DepartmentofEpidemiology,HarvardSchoolofPublic Health,Boston,Massachusetts,UnitedStatesofAmerica,3ChanningLaboratory,DepartmentofMedicine,BrighamandWomen’sHospitalandHarvardMedicalSchool, Boston,Massachusetts,UnitedStatesofAmerica Abstract Background: Rotating night shift work disrupts circadian rhythms and has been associated with obesity, metabolic syndrome,andglucosedysregulation.However,itsassociationwithtype2diabetesremainsunclear.Therefore,weaimed toevaluatethisassociationintwocohortsofUSwomen. MethodsandFindings:Wefollowed69,269womenaged42–67inNurses’HealthStudyI(NHSI,1988–2008),and107,915 women aged 25–42 in NHS II (1989–2007) without diabetes, cardiovascular disease, and cancer at baseline. Participants wereaskedhowlongtheyhadworkedrotatingnightshifts(definedasatleastthreenights/monthinadditiontodaysand eveningsinthatmonth)atbaseline.Thisinformationwasupdatedevery2–4yearsinNHSII.Self-reportedtype2diabetes wasconfirmedbyavalidatedsupplementaryquestionnaire.Wedocumented6,165(NHSI)and3,961(NHSII)incidenttype 2 diabetes cases during the 18–20 years of follow-up. In the Cox proportional models adjusted for diabetes risk factors, durationofshiftworkwasmonotonicallyassociatedwithanincreasedriskoftype2diabetesinbothcohorts.Compared withwomenwhoreportednoshiftwork,thepooledhazardratios(95%confidenceintervals)forparticipantswith1–2,3–9, 10–19,and$20yearsofshiftworkwere1.05(1.00–1.11),1.20(1.14–1.26),1.40(1.30–1.51),and1.58(1.43–1.74,p-valuefor trend,0.001),respectively.Furtheradjustmentforupdatedbodymassindexattenuatedtheassociation,andthepooled hazardratioswere1.03(0.98–1.08),1.06(1.01–1.11),1.10(1.02–1.18),and1.24(1.13–1.37,p-valuefortrend,0.001). Conclusions: Our results suggest that an extended period of rotating night shift work is as