RUNX3 Has an Oncogenic Role in Head and Neck Cancer 英文参考文献.docVIP

下载本文档

1
0
约4.73万字
约 12页
2017-05-13 发布于上海
举报
版权申诉

RUNX3 Has an Oncogenic Role in Head and Neck Cancer 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

RUNX3HasanOncogenicRoleinHeadandNeckCancer TakaakiTsunematsu1,YasuseiKudo1*,ShinjiIizuka1,IkukoOgawa2,TsuyoshiFujita3,HidemiKurihara3, YoshimitsuAbiko4,TakashiTakata1* 1Division of Frontier Medical Science, Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan,2CenterofOralClinicalExamination,HiroshimaUniversityHospital,Hiroshima,Japan,3DivisionofFrontierMedicalScience,DepartmentofPeriodontalMedicine, GraduateSchoolofBiomedicalSciences,HiroshimaUniversity,Hiroshima,Japan,4DepartmentofBiochemistry,SchoolofDentistryatMatsudo,NihonUniversity,Tokyo, Japan Abstract Background:Runt-relatedtranscriptionfactor3(RUNX3)isatumorsuppressorofcancerandappearstobeanimportant component of the transforming growth factor-beta (TGF-?)-induced tumor suppression pathway. Surprisingly, we found thatRUNX3expressionlevelinheadandnecksquamouscellcarcinoma(HNSCC)tissues,whichisoneofthemostcommon types of human cancer, was higher than that in normal tissues by a previously published microarray dataset in our preliminarystudy.Therefore,hereweexaminedtheoncogenicroleofRUNX3inHNSCC. Principal Findings: Frequent RUNX3 expression and its correlation with malignant behavior were observed in HNSCC. Ectopic RUNX3 overexpression promoted cell growth and inhibited serum starvation-induced apoptosis and chemotherapeutic drug induced apoptosis in HNSCC cells. These findings were confirmed by RUNX3 knockdown. Moreover,RUNX3overexpressionenhancedtumorsphereformation.RUNX3expressionlevelwaswellcorrelatedwiththe methylationstatusinHNSCCcells.Moreover,RUNX3expressionwaslowduetothemethylationofitspromoterinnormal oralepithelialcells. Conclusions/Significance: Our findings suggest that i) RUNX3 has an oncogenic role in HNSCC, ii) RUNX3 expression observedinHNSCCmaybecausedinpartbydemethylationduringcancerdevelopment,andiii)RUNX3expressioncanbe ausefulmarkerforpredictingmalignantbehaviorandtheeffectofchemotherapeuticdrugsinHNSCC. C