Safety and Efficacy of Dihydroartemisinin-Piperaquine in Falciparum Malaria A Prospective Multi-Centre Individual Patient Data Analysis 英文参考文献.docVIP

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Safety and Efficacy of Dihydroartemisinin-Piperaquine in Falciparum Malaria A Prospective Multi-Centre Individual Patient Data Analysis 英文参考文献.doc

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Safety and Efficacy of Dihydroartemisinin-Piperaquine in Falciparum Malaria A Prospective Multi-Centre Individual Patient Data Analysis 英文参考文献

SafetyandEfficacyofDihydroartemisinin-Piperaquinein FalciparumMalaria:AProspectiveMulti-Centre IndividualPatientDataAnalysis JulienZwang1,ElizabethA.Ashley1,CorineKarema6,7,UmbertoD’Alessandro7,FrankSmithuis4 ,Grant Dorsey9,BartJanssens8,MayfongMayxay3,5,10,PaulNewton5,PratapSinghasivanon2 ,Kasia Stepniewska2,3,NicholasJ.White2,3,Franc?oisNosten1,2,3 * 1Shoklo Malaria Research Unit, Mae Sot, Thailand, 2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 3Centre for Tropical Medicine, Nuffield Department ofClinical Medicine,UniversityofOxford,CCVTM, Oxford,United Kingdom, 4Me′decins SansFrontie`res-Holland,Yangon,Myanmar, 5Wellcome Trust– MahosotHospital–OxfordTropicalMedicineResearchCollaboration,MahosotHospital,Vientiane,Laos,6NationalMalariaControlProgramme,Kigali,Rwanda,7Institute ofTropicalMedicine,Antwerp,Belgium,8Me′decinsSansFrontie`res- Belgium,PhnomPenh,Cambodia,9DepartmentofMedicine,UniversityofCaliforniaSanFrancisco, SanFrancisco,California,UnitedStatesofAmerica,10DepartmentofPostgraduateStudiesandResearch,UniversityofHealthSciences,Vientiane,Laos Abstract Background: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-basedcombinationtherapy(ACT).Wepresentanindividualpatientdataanalysisofefficacyandtolerabilityin acuteuncomplicatedfalciparummalaria,fromsevenpublishedrandomizedclinicaltrialsconductedinAfricaandSouthEast Asiausingapredefinedin-vivoprotocol.Comparatordrugsweremefloquine-artesunate(MAS3)inThailand,Myanmar,Laos and Cambodia; artemether-lumefantrine in Uganda; and amodiaquine+sulfadoxine-pyrimethamine and artesunate+amo- diaquineinRwanda. MethodsandFindings:Intotal3,547patientswereenrolled:1,814patients(32%childrenunderfiveyears)receivedDPand 1,733receivedacomparatorantimalarialat12differentsitesandwerefollowedfor28–63days.Therewasnosignificant heterogeneitybetweentrials.DPwaswelltoleratedwith1.7%earlyvomiting.TherewerelessadverseeventswithDPin children and adu