Rumors of Its Disassembly Have Been Greatly Exaggerated The Secret Life of the Synaptonemal Complex at the Centromeres 英文参考文献.docVIP

Perspective RumorsofItsDisassemblyHaveBeenGreatly Exaggerated:TheSecretLifeoftheSynaptonemal ComplexattheCentromeres SatomiTakeo1,2,R.ScottHawley1,3 * 1StowersInstituteforMedicalResearch,KansasCity,Missouri,UnitedStatesofAmerica,2GraduateSchoolofLifeandEnvironmentalSciences,UniversityofTsukuba, Ibaraki,Japan,3DepartmentofMolecularandIntegrativePhysiology,KansasUniversityMedicalCenter,KansasCity,Kansas,UnitedStatesofAmerica The synaptonemal complex (SC) and thecentromereshavelongbeenthoughtto play their roles at quite different, non- overlapping periods during meiosis. The SCisviewed asahallmark structurethat connectshomologouschromosomesandis functionally critical for early prophase (zygotene and pachytene), while centro- meres are known to assemble the kineto- chore,actasatargetformicrotubules,and transversefilamentsthat,liketheteethofa zipper, serve to connect the two lateral elements of the SC (and include the mammalianSYCP1protein);andasetof proteins located at the center of the SC (cleverly referred to as central element proteins). Unlike SC breakdown along the chro- mosomearmsfollowingtheendofpachy- tene,themuchlaterdissolutionoftheSC at the centromeres may be a temporally complexprocessinwhichatleastoneSC component remains at the centromeres. Consistent with previous observations, The question thus arises as to the functionoftheseshortregionsofSCthat survive the end of pachytene. Studies in yeasthaveclearlyshownthatthemainte- nance of centromeric pairing by short regionsoftheSCplaysaroleinmediating thesegregationofbothexchangeandnon- bothBisigetal.[10]andQiaoetal.[11] show that while SYCP1 becomes unde- tectablepriortoNuclearEnvelopeBreak- down,SYCP3remainsassociatedwiththe centromeres until at least anaphase I in males.Qiaoetal.alsosuggestthatinsome cases the persistence of SYCP3 at the centromere may provide a ‘‘bridge be- tween the two homologous kinetochores’’ atdiakinesis/metaphaseI.Studiesinother organisms support the view that such SYCP3 bridge