Safety of carboxymethylcellulosepolyethylene oxide for the prevention of adhesions in lumbar disc herniation – consecutive case series review 英文参考文献.docVIP

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Safety of carboxymethylcellulosepolyethylene oxide for the prevention of adhesions in lumbar disc herniation – consecutive case series review 英文参考文献.doc

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Safety of carboxymethylcellulosepolyethylene oxide for the prevention of adhesions in lumbar disc herniation – consecutive case series review 英文参考文献

Annals of Surgical Innovation and Research BioMedCentral Research article Open Access Safety of carboxymethylcellulose/polyethylene oxide for the prevention of adhesions in lumbar disc herniation – consecutive case series review Patrick Fransen Address: Department of Neurosurgery, Clinique du Parc Léopold, Bruxelles, Belgium Email: Patrick Fransen - fransenp@yahoo.fr Published: 30 May 2008 Received: 10 December 2007 Accepted: 30 May 2008 Annals of Surgical Innovation and Research 2008, 2:2 doi:10.1186/1750-1164-2-2 This article is available from: /content/2/1/2 ? 2008 Fransen; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Epidural fibrosis is regarded as a cause of failed back surgery syndrome (FBSS) when excessive adhesional/fibrotic scar tissue causes compression, pain or discomfort by tethering of nerve tissue to the surrounding muscle or bone. Fibrosis inhibitors could therefore increase the success rate of spinal surgery and decrease the need for reoperations. In recent years, bio- resorbable gels or films for the prevention of peridural fibrosis and post-operative adhesions have been developed that look clinically promising. This included a 100% synthetic, sterile, absorbable gel combinations of carboxymethylcellulose (CMC) and polyethylene oxide (PEO) used to coat the dura to reduce scarring after discectomy which became available in Europe in 2002. However, given the burden of the problem and unfavorable experience with other types of adhesion-reduction agents, our unit decided to evaluate the safety of CMC/PEO in a large population of patients undergoing spinal microdiscectomy for herniation. Methods: To determine the safety and assess efficacy