Sclerosing rhabdomyosarcoma presenting in the masseter muscle a case report 英文参考文献.docVIP

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Sclerosing rhabdomyosarcoma presenting in the masseter muscle a case report 英文参考文献.doc

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Sclerosing rhabdomyosarcoma presenting in the masseter muscle a case report 英文参考文献

Linetal.DiagnosticPathology2013,8:18 /content/8/1/18 CASE REPORT OpenAccess Sclerosingrhabdomyosarcomapresentinginthe massetermuscle:acasereport Xu-YongLin1,2,YanWang1,2,Juan-HanYu1,2,YangLiu1,2,LiangWang1,2,Qing-ChangLi1,2andEn-HuaWang1,2* Abstract:Sclerosingrhabdomyosarcoma(SRMS)isexceedinglyrare,andmaycauseagreatdiagnosticconfusion. Histologically,itischaracterizedbyabundantextracellularhyalinizedmatrixmimickingprimitivechondroidor osteoidtissue.So,itmaybeeasilymisdiagnosedaschondrosarcoma,osteosarcoma,angiosarcomaandsoon. Herein,wereportacaseofSRMSoccurringinthemassetermuscleina40-year-oldmale.Thetumorshoweda diversehistologicalpattern.Thetumorcellswerearrangedintonests,cords,pseudovascular,adenoid,microalveoli andevensingle-filearrays.ImmunostainingshowedthatthetumorwaspositivefortheVimentin,Desminand MyoD1,andwasnegativeforCK,P63,NSE,CD45,CD30,S-100,CD99,Myoglobin,CD68,CD34,CD31,andα–SMA. Basedonthemorphologicalfindingandimmunostaining,itwasdiagnosedasaSRMS.Inaddition,focally,ourcase alsodisplayedacribriformpatternresemblingadenoidcysticcarcinoma.Thismayrepresentanewhistological featurewhichcanbroadenthehistologicalspectrumofthistumorandalsomayleadtodiagnosticconfusion. Virtualslides:Thevirtualslide(s)forthisarticlecanbefoundhere:http://www.diagnosticpathology.diagnomx.eu/ vs/1615846455818924 Keywords:Sclerosingrhabdomyosarcoma,Rhabdomyosarcoma,Sarcoma Background osteoid or chondroid material [18]. So, it is easily mis- Rhabdomyosarcoma (RMS) is relatively uncommon in diagnosed, if one unfamiliar with the histological all soft tissue tumors,and also rare in adults older than spectrumofthisentity.Herein,wereportacaseofscler- 45years[1].However,itisthemostcommonsofttissue osing rhabdomyosarcoma arising in masseter muscle in sarcoma in children. In the current WHO soft tissue a40-year-oldmale.Inadditiontotheabovehistological tumor classification, RMS is divided into three groups: features, the cribriform pattern resembling adenoid cys- embryonal (ER