Screening the United States Blood Supply for West Nile Virus A Question of Blood, Dollars, and Sense 英文参考文献.docVIP

respPectives Screening the United States Blood Supply for West Nile Virus: A Question of Blood, Dollars, and Sense Bruce Y. Lee*, Brad J. Biggerstaff N ow that the media frenzy over West Nile virus (WNV) has subsided, and pictures of Box 1. Korves and Colleagues’ 2006 Study Korves and colleagues constructed a Markov model simulating patients receiving blood transfusions under nine different screening strategies: (1) only administering a donor questionnaire, (2) year-round testing of 16-sample minipools (for a de?nition of minipool testing, see section entitled The Question May Be Not Only Whether to Pool, but How Much to Pool ), (3) seasonal (i.e., May through November) testing of 16-sample minipools, (4) year-round testing of six- sample minipools, (5) seasonal testing of six-sample minipools, (6) year-round individual donor testing, (7) seasonal individual donor testing, (8) year-round individual testing of donations designated for immunocompromised recipients, and (9) seasonal individual testing of donations designated for immunocompromised recipients. They assumed that test-kit cost per sample would be US$3 for individual testing, US$0.50 for six-sample minipool testing, and US$0.19 for 16- sample minipool testing; determined a US$19 laboratory technician hourly rate; added additional testing costs such as the costs of discarded samples (US$90) and donor noti?cation (US$500); and abstracted disease costs from the literature. They found that in high WNV prevalence areas, seasonal individual donation screening of blood designated for immunocompromised recipients would be most cost-effective and, in fact, cost saving, whereas in areas with low prevalence, using a donor questionnaire alone would be most cost-effective. dead birds and insect repellant cans no longer permeate the nightly news, what shall we do about screening the United States blood supply for the virus? Shortly after the spread of WNV in North America and the revelation that blood transfusions may