SEED Servers High-Performance Access to the SEED Genomes, Annotations, and Metabolic Models 英文参考文献.docVIP
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SEED Servers High-Performance Access to the SEED Genomes, Annotations, and Metabolic Models 英文参考文献
SEEDServers:High-PerformanceAccesstotheSEED
Genomes,Annotations,andMetabolicModels
RamyK.Aziz1,4,5*¤,ScottDevoid1,2,TerrenceDisz1,2,RobertA.Edwards2,4,ChristopherS.Henry1,2
,
GaryJ.Olsen6,RobertOlson1,2,RossOverbeek3*,BruceParrello3,GordonD.Pusch3,RickL.Stevens1,7,
VeronikaVonstein3,FangfangXia1,2
1ComputationInstitute,UniversityofChicago,Chicago,Illinois,UnitedStatesofAmerica,2MathematicsandComputerScienceDivision,ArgonneNationalLaboratory,
Argonne,Illinois,UnitedStatesofAmerica,3FellowshipforInterpretationofGenomes,BurrRidge,Illinois,UnitedStatesofAmerica,4DepartmentofComputerScience,
SanDiegoStateUniversity,SanDiego,California,UnitedStatesofAmerica,5DepartmentofMicrobiologyandImmunology,FacultyofPharmacy,CairoUniversity,Cairo,
Egypt,6DepartmentofMicrobiology,UniversityofIllinoisatUrbana-Champaign,Urbana,Illinois,UnitedStatesofAmerica,7Computing,Environment,andLifeSciences,
ArgonneNationalLaboratory,Argonne,Illinois,UnitedStatesofAmerica
Abstract
The remarkable advance in sequencing technology and the rising interest in medical and environmental microbiology,
biotechnology, and synthetic biology resulted in a deluge of published microbial genomes. Yet, genome annotation,
comparison,andmodelingremainamajorbottlenecktothetranslationofsequenceinformationintobiologicalknowledge,
hence computational analysis tools are continuously being developed for rapid genome annotation and interpretation.
Amongtheearliest,mostcomprehensiveresourcesforprokaryoticgenomeanalysis,theSEEDproject,initiatedin2003as
anintegrationofgenomicdataandanalysistools,nowcontains.5,000completegenomes,aconstantlyupdatedsetof
curatedannotationsembodiedinalargeandgrowingcollectionofencodedsubsystems,aderivedsetofproteinfamilies,
andhundredsofgenome-scalemetabolicmodels.Untilrecently,however,maintainingcurrentcopiesoftheSEEDcodeand
dataatremotelocationshasbeenapressingissue.Toallowhigh-performanceremoteaccesstotheSEEDdatabase,we
developedtheSEEDServers(/servers):fournetwork-basedserversintendedtoexpo
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