Selfish Little Circles Transmission Bias and Evolution of Large Deletion-Bearing Mitochondrial DNA in Caenorhabditis briggsae Nematodes 英文参考文献.docVIP

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Selfish Little Circles Transmission Bias and Evolution of Large Deletion-Bearing Mitochondrial DNA in Caenorhabditis briggsae Nematodes 英文参考文献.doc

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Selfish Little Circles Transmission Bias and Evolution of Large Deletion-Bearing Mitochondrial DNA in Caenorhabditis briggsae Nematodes 英文参考文献

SelfishLittleCircles:TransmissionBiasandEvolutionof LargeDeletion-BearingMitochondrialDNAin CaenorhabditisbriggsaeNematodes KatieA.Clark1,DanaK.Howe1,KristinGafner1,DanikaKusuma1,SitaPing1,SuzanneEstes2, DeeR.Denver1* 1DepartmentofZoologyandCenterforGenomeResearchandBiocomputing,OregonStateUniversity,Corvallis,Oregon,UnitedStatesofAmerica, 2Departmentof Biology,PortlandStateUniversity,Portland,Oregon,UnitedStatesofAmerica Abstract Selfish DNA poses a significant challenge to genome stability and organismal fitness in diverse eukaryotic lineages. Although selfish mitochondrial DNA (mtDNA) has known associations with cytoplasmic male sterility in numerous gynodioeciousplantspeciesandismanifestedaspetitemutantsinexperimentalyeastlabpopulations,examplesofselfish mtDNA in animals are less common. We analyzed the inheritance and evolution of mitochondrial DNA bearing large heteroplasmic deletions including nad5 gene sequences (nad5D mtDNA), in the nematode Caenorhabditis briggsae . The deletioniswidespreadinC.briggsaenaturalpopulationsandisassociatedwithdeleteriousorganismaleffects.Westudied theinheritancepatternsofnad5DmtDNAusingeightsetsofC.briggsaemutation-accumulation(MA)lines,eachinitiated fromadifferentnaturalstrainprogenitorandbottleneckedassinglehermaphroditesacrossgenerations.Weobserveda consistentandstrongdrivetowardhigherlevelsofdeletion-bearingmoleculesintheheteroplasmicpoolofmtDNAafter tengenerationsofbottlenecking.Ourresultsdemonstrateauniformtransmissionbiaswherebynad5DmtDNAaccumulates to higher levels relative to intact mtDNA in multiple genetically diverse natural strains of C. briggsae. We calculated an average1%per-generationtransmissionbiasfordeletion-bearingmtDNArelativetointactgenomes.Ourstudy,coupled with known deleterious phenotypes associated with high deletion levels, shows that nad5D mtDNA are selfish genetic elementsthathaveevolvedinnaturalpopulationsofC.briggsae,offeringapowerfulnewsystemtostudyselfishmtDNA dynamicsinmetazoans. Cit