Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis 英文参考文献.docVIP

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Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis 英文参考文献.doc

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Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis 英文参考文献

Available online /content/7/5/R1113 Research article Open Access Vol 7 No 5 Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis Vineeth S Rajkumar1, Kevin Howell1, Katalin Csiszar2, Christopher P Denton1, Carol M Black1 and David J Abraham1 1Centre for Rheumatology Connective Tissue Disease, Department of Medicine, Royal Free Campus, University College London, London, UK 2Cardiovascular Research Center, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA Corresponding author: David J Abraham, d.abraham@medsch.ucl.ac.uk Received: 17 May 2005 Accepted: 24 Jun 2005 Published: 21 Jul 2005 Arthritis Research Therapy 2005, 7:R1113-R1123 (DOI 10.1186/ar1790) This article is online at: /content/7/5/R1113 ? 2005 Rajkumar et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The mechanisms by which microvascular damage leads to dermal fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) are unclear. We hypothesized that microvascular pericytes constitute a cellular link between microvascular damage and fibrosis by transdifferentiating into myofibroblasts. We used a atrophic stage dcSSc skin and non-lesional skin. Using double immunofluorescence labelling, both myofibroblasts and pericytes were shown to express ED-A FN and Thy-1 in dcSSc skin but not in control skin. Proliferating cell nuclear antigen was also expressed by myofibroblasts and pericytes in dcSSc skin while being absent in control skin. These observations suggest combination of immunohistochemistry and double immunofluorescence labelling of frozen skin biopsies taken from normal and dcSSc patients to de