Signatures of human regulatory T cells an encounter with old friends and new players 英文参考文献.docVIP

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Signatures of human regulatory T cells an encounter with old friends and new players 英文参考文献.doc

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Signatures of human regulatory T cells an encounter with old friends and new players 英文参考文献

Open Access Re rch 2006PfoertneretVoal.lumesea7, Issue 7, Article R54 Signatures of human regulatory T cells: an encounter with old friends and new players Susanne Pfoertner*, Andreas Jeron*, Michael Probst-Kepper?, Carlos A Guzman?, Wiebke Hansen*, Astrid M Westendorf*, Tanja Toepfer*, Andres J Schrader§, Anke Franzke?, Jan Buer*￥ and Robert Geffers* Addresses: *Department of Mucosal Immunity, German Research Centre for Biotechnology, Braunschweig, Germany. ?Volkswagen Foundation Junior Research Group, Department of Visceral and Transplant Surgery, Hanover Medical School, Hanover, Germany. ?Department of Vaccinology, German Research Centre for Biotechnology, Braunschweig, Germany. §Department of Urology, Philipps-University Medical School, Marburg, Germany. ?Department of Hematology and Oncology, Hanover Medical School, Hanover, Germany. ￥Institute of Medical Microbiology, Hanover Medical School, Hanover, Germany. Correspondence: Jan Buer. Email: jab@gbf.de Published: 12 July 2006 Received: 6 March 2006 Revised: 16 May 2006 Accepted: 2 June 2006 Genome Biology 2006, 7:R54 (doi:10.1186/gb-2006-7-7-r54) The electronic version of this article is the complete one and can be found online at /2006/7/7/R54 ? 2006 Pfoertner et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. TsppregulatoryecCifoicmgpeanreicellssoignnsignaturesofattheuresgene./pexpression in human T regulatory cells and na?ve cells using a T regulatory cell-specific microarray reveals cell- Abstract Background: Naturally occurring CD4+CD25+ regulatory T cells (TReg) are involved in the control of autoimmune diseases, transplantation tolerance, and anti-tumor immunity. Thus far, genomic studies on TReg cells were restricted to murine syst