Significance of HE4 estimation in comparison withCA125 in diagnosis of ovarian cancer andassessment of treatment response 英文参考文献.docVIP

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Significance of HE4 estimation in comparison withCA125 in diagnosis of ovarian cancer andassessment of treatment response 英文参考文献.doc

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Significance of HE4 estimation in comparison withCA125 in diagnosis of ovarian cancer andassessment of treatment response 英文参考文献

Hamedetal.DiagnosticPathology2013,8:11 /content/8/1/11 RESEARCH OpenAccess SignificanceofHE4estimationincomparison withCA125indiagnosisofovariancancerand assessmentoftreatmentresponse ElhamOHamed1*,HydiAhmed1,OsamaBSedeek4,AbeerMMohammed1,AliAAbd-Alla2 andHazemMAbdelGhaffar3 Abstract Background:Humanepididymisprotein4(HE4)isanovelandspecificbiomarkerforovariancancer.Theaimof thisstudyistoevaluateanewtumormarker,HE4,incomparisonwithCA125indiagnosisofepithelialovarian cancer(EOC)andbenigngynecologicaldiseases. Methods:CA125andHE4serumlevelsweredeterminedin30patientswithepithelialovariancancer(21serous,6 endometrioidand3mucinoustumors),20patientswithbenigngynecologicaldiseases(8patientswithovarian cyst,5patientswithendometriosis,4patientswithfibroidand3patientswithpelvicinflammatorydisease)and20 healthywomen.CA125andHE4cut-offswere35U/mland150pmol/l,respectively. Results:SerumHE4andCA125concentrationsweresignificantlyhigherintheovariancancerpatientscompared withthoseseeninpatientswithbenigndiseaseorinthehealthycontrols(p=0.001andp0.001respectively).In thereceiveroperatingcharacteristicanalysis(ROC),theareaunderthecurve(AUC)valuesforHE4was0.96(95% confidenceinterval,0.9-1.0)andCA125was0.82(95%confidenceinterval,0.7-0.94).ComparedtoCA125,HE4had highersensitivity(90%vs.83.3%),specificity(95%vs.85%),PPV(93.1%vs.80.7%)andNPV(92.7%vs.87.2%),the combinationofHE4+CA125thesensitivityandPPVreached96.7%and97%respectively. Conclusion:MeasuringserumHE4concentrationsalongwithCA125concentrationsmayprovidehigheraccuracy fordetectingepithelialovariancancer. VirtualSlides:Thevirtualslide(s)forthisarticlecanbefoundhere:http://www.diagnosticpathology.diagnomx.eu/ vs/1060413168685759 Keywords:Humanepididymisprotein4,HE4,Carbohydrateantigen125,CA125,Epithelial,Ovariancancer,EOC Introduction is preliminary evidence that screening can improve sur- Theannual incidence of ovariancancer is204,000,with vival, but the impact of screening on mortality from 125,000 deaths. In developed countries