Simulation Study of Nano Aqueous Flow Sensor Based on Amperometric Measurement 英文参考文献.docVIP

Sensors 2006, 6, 473-479 sensors ISSN 1424-8220 ? 2006 by MDPI /sensors Simulation Study of Nano Aqueous Flow Sensor Based on Amperometric Measurement Jian Wu 1, Qingli Zhou 2, Jun Liu 1,* and Zhengguo Lou 1 1 Department of Biomedical Engineering, Zhejiang University, 38 ZheDa Road, Hangzhou 310027, PR China 2 Women’s Hospital, Zhejiang University, 2 Xueshi Road, Hangzhou 310006, PR China E-mails: bmewuj@ (Jian Wu), zhouql@ (Qingli Zhou) * Author to whom correspondence should be addressed. Fax: 0086 571Email: junliu@ Received: 10 November 2005; revised version received: 13 March 2006 / Accepted: 17 March 2006 / Published: 6 April 2006 Abstract: In this paper, a novel nano aqueous flow sensor which consists of two closely spaced amperometric sensors is investigated by digital simulation. The simulation results indicate that the ratio of the responses of two closely spaced amperometric sensors is only related to flow rates in the channel, insensitive to the analyte concentration in the solution. By comparing the output of two amperometric sensors, the flow rate in the channel can be deduced. It is not necessary to determine the analyte concentration in advance. The simulation results show it is able to detect flow rate by in the range of several nano-liters per minute when the distance between the working electrodes of two amperometric sensors is 200 nm and the cross-section of the channel is 1 μm x 1 μm. Keywords: flow sensor, amperometric sensor, channel, simulation. 1. Introduction Flow measurements have become increasingly important in the micro/nano systems for chemical analysis, drug delivery and so on [1,2]. Presently thermal measurement is still the main choice in measuring micro/nano flow of aqueous liquids [3,4]. Thermal measurement has advantages such as sensing very low flow rate. However, in order to achieve good thermal isolation, complicated MEMS structures are necessary, w