Social regulation of gene expression in human leukocytes 英文参考文献.docVIP

Open Access rch 2007ColeetVReal.umesea8, Issue 9, Article R189 Social regulation of gene expression in human leukocytes Steve W Cole*??, Louise C Hawkley§, Jesusa M Arevalo*, Caroline Y Sung?, Robert M Rose? and John T Cacioppo§ Addresses: *Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, Los Angeles CA 90095-1678, USA. ?UCLA AIDS Institute, UCLA Molecular Biology Institute, Jonsson Comprehensive Cancer Center. ?Norman Cousins Center. §Department of Psychology, and Center for Cognitive and Social Neuroscience, University of Chicago. ?Institute for Medical Humanities, University of Texas Medical Branch at Galveston, and the John D and Catherine T MacArthur Foundation. Correspondence: Steve W Cole. Email: coles@ Published: 13 September 2007 Received: 2 March 2007 Revised: 30 July 2007 Accepted: 13 September 2007 Genome Biology 2007, 8:R189 (doi:10.1186/gb-2007-8-9-r189) The electronic version of this article is the complete one and can be found online at /2007/8/9/R189 ? 2007 Cole et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. EffectstiovpreyAsgonecnaofiaelylslonelinesss.iisso/olpaftdioifnfe(ronleonntgeneeilailnlyesexpressionexpresseds) revealedinocirculatingver-expressleukocytesion f somefromantipeople-inflamwhomatochronicallyry genes anexperiencedd und r-exphighressioversusn of olowme levelspro-inofflasubjec-mma- Abstract Background: Social environmental influences on human health are well established in the epidemiology literature, but their functional genomic mechanisms are unclear. The present study analyzed genome-wide transcriptional activity in people who chronically experienced high versus low levels of subjective social isolation (loneliness