Stem Cell Therapy A New Treatment for Burns 英文参考文献.docVIP

Pharmaceuticals 2011, 4, 1355-1380; doi:10.3390/ph4101355 OPEN ACCESS Pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Stem Cell Therapy: A New Treatment for Burns? Anna Arno 1,2, Alexandra H. Smith 1, Patrick H. Blit 1, Mohammed Al Shehab 1, Gerd G. Gauglitz 3 and Marc G. Jeschke 1,* 1 Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada 2 Plastic Surgery Department and Burn Unit, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Passeig de la Vall d’Hebron 119-129, 08035, Barcelona, Spain 3 Department of Dermatology and Allergology, Ludwig Maximilians University, Geschwister-Scholl-Platz 1, 80539, Munich, Germany * Author to whom correspondence should be addressed: E-Mail: marc.jeschke@sunnybrook.ca; Tel.: +1-416-480-6703; Fax: +1-416-480-6763. Received: 12 July 2011; in revised form: 21 September 2011 / Accepted: 10 October 2011 / Published: 21 October 2011 Abstract: Stem cell therapy has emerged as a promising new approach in almost every medicine specialty. This vast, heterogeneous family of cells are now both naturally (embryonic and adult stem cells) or artificially obtained (induced pluripotent stem cells or iPSCs) and their fates have become increasingly controllable, thanks to ongoing research in this passionate new field. We are at the beginning of a new era in medicine, with multiple applications for stem cell therapy, not only as a monotherapy, but also as an adjunct to other strategies, such as organ transplantation or standard drug treatment. Regrettably, serious preclinical concerns remain and differentiation, cell fusion, senescence and signalling crosstalk with growth factors and biomaterials are still challenges for this promising multidisciplinary therapeutic modality. Severe burns have several indications for stem cell therapy, including enhancem