Study designs of randomized controlled trials not based on Chinese medicine theory are improper 英文参考文献.docVIP

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Study designs of randomized controlled trials not based on Chinese medicine theory are improper 英文参考文献.doc

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Study designs of randomized controlled trials not based on Chinese medicine theory are improper 英文参考文献

Chinese Medicine BioMedCentral Commentary Open Access Study designs of randomized controlled trials not based on Chinese medicine theory are improper Jian Yan*1, Veronica F Engle2, Yuxin He3, Yan Jiao4 and Weikuan Gu4 Address: 1Molecular Resource Center, University of Tennessee Health Science Center, Memphis, TN 38163, USA, 2Department of Primary Care Nursing and Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA, 3Acupuncture Chinese Medical Center, Austin, TX 78757, USA and 4Department of Orthopedics Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA Email: Jian Yan* - jyan1@; Veronica F Engle - vengle@; Yuxin He - Dryuxinhe@; Yan Jiao - yjiao2@; Weikuan Gu - wgu@ * Corresponding author Published: 25 February 2009 Received: 7 July 2006 Accepted: 25 February 2009 Chinese Medicine 2009, 4:3 doi:10.1186/1749-8546-4-3 This article is available from: /content/4/1/3 ? 2009 Yan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Current biomedical research methods to evaluate the efficacy of Chinese medicine interventions are often conceptually incompatible with the theory and clinical practice of Chinese medicine. In this commentary, we (1) highlight the theory and principles underlying Chinese medicine clinical practice; (2) use ginseng as an example to describe clinical indications in Chinese medicine; (3) propose a framework guided by Chinese medicine theory for the evaluation of study designs in Chinese medicine research; and (4) evaluate 19 randomized, double-blind, placebo-controlled trials of ginseng. Our analysis indicates that all 19 trials with both positive and negative results confirm the sp