Studying alternative splicing regulatory networks through partial correlation analysis 英文参考文献.docVIP

Open Access Research 2009ChenVolumande 10Zheng, Issue 1, Article R3 Studying alternative splicing regulatory networks through partial correlation analysis Liang Chen* and Sika Zheng? Addresses: *Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA. ?Howard Hughes Medical Institute, University of California, Los Angeles, MRL 6-619, Los Angeles, California 90095, USA. Correspondence: Liang Chen. Email: liang.chen@ Published: 9 January 2009 Received: 19 November 2008 Revised: 18 December 2008 Accepted: 9 January 2009 Genome Biology 2009, 10:R3 (doi:10.1186/gb-2009-10-1-r3) The electronic version of this article is the complete one and can be found online at /2009/10/1/R3 ? 2009 Chen and Zheng; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. AlternativevipdesThneovidelensplicingintsifigchattsioregulatoryinntooftlhinekasltbnetworkeetweenrnativeexonssplicinandg retheirgulatoregulatorsry networkor.targets/p and between co-spliced exons in human, mouse and rat pro- Abstract Background: Alternative pre-mRNA splicing is an important gene regulation mechanism for expanding proteomic diversity in higher eukaryotes. Each splicing regulator can potentially influence a large group of alternative exons. Meanwhile, each alternative exon is controlled by multiple splicing regulators. The rapid accumulation of high-throughput data provides us with a unique opportunity to study the complicated alternative splicing regulatory network. Results: We propose the use of partial correlation analysis to identify association links between exons and their upstream regulators or their downstream target genes (exon-