Study protocol. A prospective cohort study of unselected primiparous women the pregnancy outcome prediction study 英文参考文献.docVIP

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Study protocol. A prospective cohort study of unselected primiparous women the pregnancy outcome prediction study 英文参考文献.doc

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Study protocol. A prospective cohort study of unselected primiparous women the pregnancy outcome prediction study 英文参考文献

BMC Pregnancy and Childbirth BioMedCentral Study protocol Open Access Study protocol. A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction study Dharmintra Pasupathy1, Alison Dacey1, Emma Cook1, D Stephen Charnock- Jones1, Ian R White2 and Gordon CS Smith*1 Address: 1Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK and 2MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK Email: Dharmintra Pasupathy - dp349@cam.ac.uk; Alison Dacey - ad507@cam.ac.uk; Emma Cook - ec518@cam.ac.uk; D Stephen Charnock- Jones - dscj1@cam.ac.uk; Ian R White - ian.white@mrc-bsu.cam.ac.uk; Gordon CS Smith* - gcss2@cam.ac.uk * Corresponding author Published: 19 November 2008 Received: 7 August 2008 Accepted: 19 November 2008 BMC Pregnancy and Childbirth 2008, 8:51 doi:10.1186/1471-2393-8-51 This article is available from: /1471-2393/8/51 ? 2008 Pasupathy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: There have been dramatic changes in the approach to screening for aneuploidy over the last 20 years. However, the approach to screening for other complications of pregnancy such as intra-uterine growth restriction, pre-eclampsia and stillbirth remains largely unchanged. Randomised controlled trials of routine application of high tech screening methods to the general population have generally failed to show improvement in outcome. We have previously reviewed this and concluded it was due, in large part, to poor performance of screening tests. Here, we report a study design where the primary aim is to generate clinically useful methods to screen women to assess their risk of adverse pregnancy outcome. Methods