Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex 英文参考文献.docVIP

Molecules 2012, 17, 4915-4923; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex Rie Furuya, Honghai Hu, Zhenya Zhang and Hideyuki Shigemori * Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan * Author to whom correspondence should be addressed; E-Mail: hshige@agbi.tsukuba.ac.jp; Tel./Fax: +81-29-853-8572. Received: 14 April 2012; in revised form: 16 April 2012 / Accepted: 16 April 2012 / Published: 30 April 2012 Abstract: Two new monoterpene diglycosides, suffruyabiosides A (1) and B (2), and seven known compounds 3–9 were isolated from Moutan Cortex (root cortex of Paeonia suffruticosa Andrews). The structures were elucidated on the basis of 2D NMR spectral data. Suffruyabiosides A (1) and B (2) are rare monoterpene diglycosides, including a cellobiose in the molecules. Salicylpaeoniflorin (4) had a antiproliferation effect similar to paeoniflorin (3) on human lung adenocarcinoma epitherial A549 cells. Galloylpaeoniflorin (8) and salicylpaeoniflorin (4) revealed a more pronounced radical scavenging effect than ?-tocopherol (positive control). An increase in the number of phenolic hydroxyl groups produced a more effective radical scavenging effect [8 mudanpioside E (6) oxypaeoniflorin (5)]. Comparison of the effects of 4 and 5 showed that o-substitution with a phenolic hydroxyl group was more effective than p-substitution. The results suggest that salicylpaeoniflorin (4) may be useful as a cytotoxic and a radical scavenging agent. Keywords: monoterpene diglycoside; suffruyabiosides A and B; human lung adenocarcinoma epitherial A549 cells; radical scavenging effect 1. Introduction Moutan Cortex (root cortex of Paeonia suffruticosa Andrews) is one of the most important natural medicine