Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats 英文参考文献.docVIP

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Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats 英文参考文献.doc

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Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats 英文参考文献

Available online /content/13/4/R109 Research Open Access Vol 13 No 4 Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats Stefan Lauer1, Hendrik Freise1, Martin Westphal1, Alexander Zarbock1, Manfred Fobker2, Hugo K Van Aken1, Andreas W Sielenk?mper1 and Lars G Fischer1 1Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster, Albert-Schweitzer-Str. 33, 48149 Muenster, Germany 2Center for Laboratory Medicine, University Hospital of Muenster, Albert-Schweitzer-Str. 33, 48149 Muenster, Germany Corresponding author: Stefan Lauer, stlauer@ Received: 13 Mar 2009 Revisions requested: 5 May 2009 Revisions received: 2 Jun 2009 Accepted: 6 Jul 2009 Published: 6 Jul 2009 Critical Care 2009, 13:R109 (doi:10.1186/cc7950) This article is online at: /content/13/4/R109 ? 2009 Lauer et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Increasing evidence indicates that epidural lung tisssue) were investigated at 6 and 24 hours by using an established model of isolated and perfused lungs. anesthesia improves postoperative pulmonary function. The underlying mechanisms, however, remain to be determined. Because pulmonary nitric oxide has been identified to play a critical role in pulmonary dysfunction in sepsis, we hypothesized that thoracic epidural anesthesia (TEA) modulates endothelial dysfunction via a nitric oxide-dependent pathway. Results In hyperdynamic sepsis, treatment with TEA resulted in reduced bradykinin-induced pulmonary vasoconstriction (P 0.05) and lower levels of exhaled NO as compared with those in untreated septic rats (P 0.05). However, the development of pulmonary edema or MPO activity in the lun