Toll-like receptor 4 deficiency Smaller infarcts, but nogain in function 英文参考文献.docVIP

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Toll-like receptor 4 deficiency Smaller infarcts, but nogain in function 英文参考文献.doc

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Toll-like receptor 4 deficiency Smaller infarcts, but nogain in function 英文参考文献

BMC Physiology BioMedCentral Research article Open Access Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function Se-Chan Kim?1,5, Alexander Ghanem?2, Heidi Stapel3, Klaus Tiemann2, Pascal Knuefermann1, Andreas Hoeft1, Rainer Meyer3, Christian Grohé4, Anne A Knowlton5 and Georg Baumgarten*1 Address: 1Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany, 2Department of Internal Medicine, University of Bonn, Germany, 3Institute of Physiology, University of Bonn, Germany, 4Department of Internal Medicine, University of Bonn, Germany and 5Division of Cardiovascular Medicine, University of California, Davis, USA Email: Se-Chan Kim - sckkim@; Alexander Ghanem - Alexander.Ghanem@ukb.uni-bonn.de; Heidi Stapel - heidistapel@uni- bonn.de; Klaus Tiemann - k-tiemann@uni-bonn.de; Pascal Knuefermann - knuefermann.pascal@ukb.uni-bonn.de; Andreas Hoeft - Andreas.Hoeft@ukb.uni-bonn.de; Rainer Meyer - rainer.meyer@ukb.uni-bonn.de; Christian Grohé - c.grohe@uni-bonn.de; Anne A Knowlton - aaknowlton@; Georg Baumgarten* - Georg.Baumgarten@ukb.uni-bonn.de * Corresponding author ?Equal contributors Published: 25 June 2007 Received: 23 December 2006 Accepted: 25 June 2007 BMC Physiology 2007, 7:5 doi:1 0.1 1 86/1 472-6793-7-5 This article is available from: /1 472-6793/7/5 ? 2007 Kim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Backgound: It has been reported that Toll-like receptor 4 (TLR4) deficiency reduces infarct size after myocardial ischemia/reperfusion (MI/R). However, measurement of MI/R injury was limited and did not include cardiac function. In a chronic closed-chest model we assessed whether cardiac function is preserved in TLR4-deficient mice (C3H/HeJ) follo