Time to tackle clonorchiasis in China 英文参考文献.docVIP

TimetotackleclonorchiasisinChina Qianetal. Qianetal.InfectiousDiseasesofpoverty2013,2:4 /content/2/1/4  Qianetal.InfectiousDiseasesofpoverty2013,2:4 /content/2/1/4 OPINION OpenAccess TimetotackleclonorchiasisinChina Men-BaoQian1*,Ying-DanChen1andFeiYan2 Abstract Recentpublicationoftheglobalepidemiologyofclonorchiasisanditsrelationshipwithcholangiocarcinomainthe journalofInfectiousDiseasesofPovertyhasstressedtheimportanceofClonorchissinensisinfection.Tofurther demonstrateitsthreatonpublichealth,especiallyinChina,comparisonsbetweenclonorchiasisandhepatitisBare madeintermsofepidemiology,clinicalsymptomsandcarcinogenicity,disability,aswellaschangingtrends. Furthermore,majorproblemsandprioritizedresearchesareargued,frombasicbiologytointervention.Imbalance betweenthemajorityofinfectedpopulationandtheminorityofresearchesinChinaurgesformoreworkfrom Chinesescientistsandinternationalcooperation. Keywords:Clonorchissinensis,Clonorchiasis,HepatitisBvirus,Livercancer,Research Multilingualabstracts infections. A total population of 93 million is infected Please see Additional file 1 for translations of the ab- with HBV in China, which is about one quarter of the stract into the six official working languages of the global number [3,4], while out of 15 million with C. UnitedNations. sinensisinfectionglobally,over85%distributesinChina (Figure1A)[1].Evenafterincludinganotherliverflukein- fection,opisthorchiasis,thenumberinChinaisstillover 50%(Figure2B)[1,5,6].Similardistributioncharacteristics in sexes and ages are shown in both infections, namely higherprevalenceinmalesthaninfemalesandinadults thaninchildren[1,7]. Background A review on the global epidemiology of clonorchiasis anditsrelationshipwithcholangiocarcinoma(CCA)was publishedinthejournalofInfectiousDiseasesofPoverty on 25th October 2012 [1]. A total of 15 million people Secondly, as HBV mainly attacks the liver, C. sinensis infection also causes liver diseases, as well as biliary conditions.Althoughtherearedifferen