Time-point measurement is critical in hormone characterization 英文参考文献.docVIP

Available online /content/10/2/411 Letter Time-point measurement is critical in hormone characterization Samuel Colby Danna Louisiana State University Health, Sciences Center in New Orleans, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA Corresponding author: Samuel Colby Danna, sdanna@ Published: 27 April 2006 Critical Care 2006, 10:411 (doi:10.1186/cc4914) This article is online at /content/10/2/411 ? 2006 BioMed Central Ltd See related research by Nematy et al. in issue 10.1 [/content/10/1/R10] In their recent study ‘Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study’ Nematy and colleagues further elucidated intensive care unit (ICU) patients’ poor nutritional status. They reported high levels of peptide YY (PYY) and low levels of ghrelin in fasting plasma samples from ICU patients compared with healthy, nonhospitalized controls [1]. While intriguing, this gives only a mere snapshot of PYY/ghrelin physiology in the ICU patient because PYY/ghrelin levels were measured only once per day. while still exhibiting a higher/lower baseline state. This is representative of a suboptimal physiologic response. A rhythmic response may still be present but sufficient hormone levels are not reached, resulting in a less potent stimulus leading to a depressed response. This is the most probable case as it is possible that the hormone response in critically ill patients may be inadequate. This could therefore hold true for PYY/ghrelin responses, in which normal stimuli do not enhance the hormone response. The pattern of plasma ghrelin levels during a 24-hour period in human subjects was previously characterized, in which samples were taken at intervals of 30–60 min throughout the day. Results revealed a preprandial rise and a postprandial decline in ghrelin, characteristic of a n