Two New Chroman Derivations from the Endophytic Penicillium sp. DCS523 英文参考文献.docVIP

Molecules 2011, 16, 686-693; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two New Chroman Derivations from the Endophytic Penicillium sp. DCS523 Jun-Tian Li 1,2, Xiao-Li Fu 1, Chun Tan 3, Ying Zeng 1, Qi Wang 2 and Pei-Ji Zhao 1,* 1 The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China 2 Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China 3 College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, China * Author to whom correspondence should be addressed; E-Mail: zhaopeiji@; Tel.: +86-871-5223111; Fax: +86-871-5150227. Received: 2 December 2010; in revised form: 24 December 2010 / Accepted: 28 December 2010 / Published: 18 January 2011 Abstract: Strain DCS523 was isolated from the branch tissue of Daphniphyllum longeracemosum and determined to be a Penicillium sp. according to the ITS sequence analysis. The extracts from the PDA solid fermentation media of Penicillium sp. DCS523 were purified to give two new chroman derivatives as well as six known compounds. Based on their spectral data the new compounds were identified as (Z)-6-acetyl- 3-(1,2-dihydroxypropylidene)-5-hydroxy-8-methylchroman-2-one (1) and 6-acetyl-2α,5- dihydroxy-2-(2-hydroxypropyl)- 3α,8-dimethylchroman (2), respectively. Keywords: chroman derivations; endophytic; Penicillium sp.; ITS sequence 1. Introduction Plant endophytes are a group of microorganisms, including fungi and bacteria, which not only live within plant internal tissues or organs without causing any apparent symptoms or diseases in the host plants, but also serve as important sources of bioactive compounds, presumably due to the symbiotic relationship with their hosts [1]. I